Organochlorines and risk of prostate cancer

Details

• Personal Author:
  Fuortes LJ ; Guo H ; Reedy VE ; Ritchie JM ; Smith EM ; Vial SL
• Description:
  This pilot study examined the relationships of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) with prostate cancer. Ninety-nine controls were frequency matched by age in 5-year increments to 58 prostate cancer patients. Thirty PCBs and 18 OCPs were measured in serum by gas chromatography. Multiple logistic regression was used to assess the magnitude of association. Seven organochlorines, dieldrin, p,p'-DDE, trans-nonachlor, oxychlordane, heptachlor epoxide, and PCBs 153 and 180 were detected in at least 20% of all study participants. Adjusting for age, body mass index, and a history of prostatitis, oxychlordane and PCB 180 were associated with an increased risk of prostate cancer. This study suggests that long-term, low-dose exposure to specific OCPs and PCBs in the general population may contribute to an increased risk of prostate cancer and supports further investigation in this area. [Description provided by NIOSH]
• Subjects:
  Aging Chlorine Compounds Chromatography Environmental Exposure Epidemiology Hazardous Substances Insecticides Men Neoplasms Occupational Health Polychlorinated Biphenyls Risk Assessment Risk Factors Safety Surveys And Questionnaires Urogenital Diseases Urogenital System

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• Keywords:
  Age-groups Blood-serum Cancer Chromatographic-analysis Environmental-exposure Exposure-levels Exposure-limits Humans Organo-chlorine-compounds Pesticides Pesticides-and-agricultural-chemicals Polychlorinated-biphenyls Prostate-cancer Questionnaires Risk-factors Statistical-analysis Toxins

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• ISSN:
  1076-2752
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Iowa ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  45
• Issue:
  7
• NIOSHTIC Number:
  nn:20040694
• Citation:
  J Occup Environ Med 2003 Jul; 45(7):692-702
• Contact Point Address:
  Justine M. Ritchie, PhD, Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, IA 52242
• Email:
  jritchie@mail.public-health.uiowa.edu
• CAS Registry Number:
  1,1′-Biphenyl, chloro derivs. (CAS RN 1336-36-3) ; Dieldrin (CAS RN 60-57-1) ; PCB-1254 (CAS RN 11097-69-1)
• Federal Fiscal Year:
  2003
• Performing Organization:
  University of Iowa
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• End Date:
  20290630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:00decb8eea8c6958980fcb73f2266b5beda95e864e414ebb319e1b64b5c8df78dbec6375eeebf96c7b87b705c4bbf6c6088cad3aebb977c5aecf108e43a245a8
• Download URL:
  https://stacks.cdc.gov/view/cdc/193478/cdc_193478_DS1.pdf
• File Type:
  [PDF - 354.53 KB ]