Metabolic syndrome is associated with increased breast cancer risk: a systematic review with meta-analysis

Details

• Personal Author:
  Bhandari R ; Hartley TA ; Kelley GA ; Rockett IRH
• Description:
  Background: Although individual metabolic risk factors are reported to be associated with breast cancer risk, controversy surrounds risk of breast cancer from metabolic syndrome (MS). We report the first systematic review and meta-analysis of the association between MS and breast cancer risk in all adult females. Methods: Studies were retrieved by searching four electronic reference databases [PubMed, Cumulative Index to Nursing and Allied Health Literature (CINAHL),Web of Science, and ProQuest through June 30, 2012] and cross-referencing retrieved articles. Eligible for inclusion were longitudinal studies reporting associations between MS and breast cancer risk among females aged 18 years and older. Relative risks and 95% confidence intervals were calculated for each study and pooled using random-effects models. Publication bias was assessed quantitatively (Trim and Fill) and qualitatively (funnel plots). Heterogeneity was examined using Q and I 2 statistics. Results: Representing nine independent cohorts and 97,277 adult females, eight studies met the inclusion criteria. A modest, positive association was observed between MS and breast cancer risk (RR: 1.47, 95% CI, 1.15-1.87; z = 3.13; p = 0.002; Q = 26.28, p = 0.001; I 2 = 69.55%). No publication bias was observed. Conclusions: MS is associated with increased breast cancer risk in adult women. [Description provided by NIOSH]
• Subjects:
  Aging Blood Body Weight Energy Metabolism Epidemiology Genetics Hematologic Tests Neoplasms Occupational Health Risk Assessment Risk Factors Safety Women

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• Keywords:
  Age-groups Blood-samples Body-weight Breast-cancer Cancer Humans Metabolic-study Models Risk-factors Statistical-analysis
• ISSN:
  2090-3189
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; OSHA Region 3 ; OSHA Region 4 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  2014
• NIOSHTIC Number:
  nn:20046182
• Citation:
  Int J Breast Cancer 2014 Dec; 2014:189384
• Contact Point Address:
  Ruchi Bhandari, Department of Epidemiology, School of Public Health,West Virginia University, Morgantown, WV 26506
• Email:
  bhandariruchi@yahoo.com
• Federal Fiscal Year:
  2015
• Peer Reviewed:
  True
• Source Full Name:
  International Journal of Breast Cancer
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:546f2f5523e9c9b5b495bfca2be15c0a5ab003af94b176d520775cd2d26623590055899c4085857176cf3fe00d7867feaaffee2b78e7b51822ff6c438c2009e1
• Download URL:
  https://stacks.cdc.gov/view/cdc/201309/cdc_201309_DS1.pdf
• File Type:
  [PDF - 1.37 MB ]