Polymorphisms in the p53 pathway genes and micronucleus occurrence in Chinese vinyl chloride-exposed workers

Details

• Personal Author:
  Brandt-Rauf P ; Feng N-N ; Hao Y-H ; Li Y ; Long C ; Nanzhang Y ; Wang Q ; Xia Z-L ; Zhang G-H
• Description:
  OBJECTIVES: To investigate the association between polymorphisms in the p53 pathway genes and chromosomal damage in vinyl chloride (VC)-exposed workers. MATERIALS AND METHODS: Cytokinesis block micronucleus test was performed in 310 VC-exposed workers and 149 non-exposed workers to determine chromosomal damage. The polymerase chain reaction and restriction fragment length polymorphism technique were used to detect six SNPs in the p53 pathway genes involved in the cell cycle. RESULTS: There was a highly significant dose-response relationship between VC exposure and chromosomal damage. Individuals carrying the variant genotypes were at higher risk for chromosomal damage compared with their wild type genotype: p53rs1042522, MDM2 Del1518rs3730485, MDM2rs2279744 and GADD45Ars532446. On the other hand, individuals possessing the variant genotype of CDKN2A rs3088440 had significantly decreased risk compared with the corresponding wild-type. CONCLUSIONS: Genetic polymorphisms in P53 pathway genes may have an impact on VC-induced chromosomal damage. [Description provided by NIOSH]
• Subjects:
  Cell Division Chlorine Genetics Occupational Exposure Occupational Health Safety
• Keywords:
  Author Keywords: VC Cell Division Chlorides DNA Damage Dose Response Genes Genetic Factors Genetic Polymorphism Occupational Exposure P53 Pathway Genes
• ISSN:
  1232-1087
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Illinois ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  26
• Issue:
  6
• NIOSHTIC Number:
  nn:20046080
• Citation:
  Int J Occup Med Environ Health 2013 Dec; 26(6):825-836
• Contact Point Address:
  Yong Li, Department of Occupational Health and Toxicology, School of Public Health, Fudan University, Shanghai, China
• CAS Registry Number:
  Vinyl chloride (CAS RN 75-01-4)
• Federal Fiscal Year:
  2014
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  University of Illinois at Chicago
• Peer Reviewed:
  True
• Start Date:
  20010701
• Source Full Name:
  International Journal of Occupational Medicine and Environmental Health
• End Date:
  20150831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:48c069def6c530c82587c33572f7e3407616ae6cdf47a990c4fab343738d574a1a0bd214f3bb345dd2ce79e441bad8b3c48da8e0cab24d75ef31f3d075309480
• Download URL:
  https://stacks.cdc.gov/view/cdc/201252/cdc_201252_DS1.pdf
• File Type:
  [PDF - 209.99 KB ]