Investigations of immunotoxicity and allergic potential induced by topical application of triclosan in mice

Details

• Personal Author:
  Anderson, Stacey E. ; Long CM ; Lukomska E ; Marshall NB ; Meade BJ
• Description:
  Triclosan is an antimicrobial chemical commonly used occupationally and by the general public. Using select immune function assays, the purpose of these studies was to evaluate the immunotoxicity of triclosan following dermal exposure using a murine model. Triclosan was not identified to be a sensitizer in the murine local lymph node assay (LLNA) when tested at concentrations ranging from 0.75-3.0%. Following a 28-day exposure, triclosan produced a significant increase in liver weight at concentrations of >/=1.5%. Exposure to the high dose (3.0%) also produced a significant increase in spleen weights and number of platelets. The absolute number of B-cells, T-cells, dendritic cells and NK cells were significantly increased in the skin draining lymph node, but not the spleen. An increase in the frequency of dendritic cells was also observed in the lymph node following exposure to 3.0% triclosan. The IgM antibody response to sheep red blood cells (SRBC) was significantly increased at 0.75% - but not at the higher concentrations - in the spleen and serum. These results demonstrate that dermal exposure to triclosan induces stimulation of the immune system in a murine model and raise concerns about potential human exposure. [Description provided by NIOSH]
• Subjects:
  Antibodies Biological Assay Environmental Monitoring Hazardous Substances Hypersensitivity Immune System Laboratories Liver Occupational Health Safety Skin

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• Keywords:
  Allergic-reactions Antibody-response Author Keywords: Hypersensitivity Bioassays Cell-alteration Cellular-reactions Exposure-assessment Exposure-levels Exposure-methods Immune-reaction Immune-system Immune Suppression Immunological-tests Immunotoxicity Immunotoxins Laboratory-animals Laboratory-testing Liver-disorders Lymph-nodes Platelets Red-blood-cells Skin-exposure Spleen-disorders Toxic-effects Triclosan Weight-factors

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• ISSN:
  1547-691X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  165-172
• Volume:
  13
• Issue:
  2
• NIOSHTIC Number:
  nn:20046069
• Citation:
  J Immunotoxicol 2016 Mar; 13(2):165-172
• Contact Point Address:
  Stacey Anderson, PhD, National Institute for Occupational Safety and Health (NIOSH), 1095 Willowdale Drive, Morgantown, WV 26505
• Email:
  sanderson4@cdc.gov
• CAS Registry Number:
  Triclosan (CAS RN 3380-34-5)
• Federal Fiscal Year:
  2016
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Immunotoxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c1cc1192fd1d48d8478b16fd5b82644ba4676054b74fd3f79ae379434c4b640cf8e210625d98f711592d3cb032d3d299bd6aab799927f01588656789a0e155d3
• Download URL:
  https://stacks.cdc.gov/view/cdc/201244/cdc_201244_DS1.pdf
• File Type:
  [PDF - 396.96 KB ]