Urinary melatonin concentration and the risk of breast cancer in Nurses' Health Study II

Details

• Personal Author:
  Arcaro KF ; Brown SB ; Eliassen AH ; Hankinson SE ; Qian J ; Reeves KW ; Schernhammer ES ; Wegrzyn LR ; Willett WC
• Description:
  Experimental and epidemiologic data support a protective role for melatonin in breast cancer etiology, yet studies in premenopausal women are scarce. In a case-control study nested within the Nurses' Health Study II cohort, we measured the concentration of melatonin's major urinary metabolite, 6-sulfatoxymelatonin (aMT6s), in urine samples collected between 1996 and 1999 among 600 breast cancer cases and 786 matched controls. Cases were predominantly premenopausal women who were diagnosed with incident breast cancer after urine collection and before June 1, 2007. Using multivariable conditional logistic regression, we computed odds ratios and 95% confidence intervals. Melatonin levels were not significantly associated with total breast cancer risk (for the fourth (top) quartile (Q4) of aMT6s vs. the first (bottom) quartile (Q1), odds ratio (OR) = 0.91, 95% confidence interval (CI): 0.64, 1.28; Ptrend = 0.38) or risk of invasive or in situ breast cancer. Findings did not vary by body mass index, smoking status, menopausal status, or time between urine collection and diagnosis (all Pinteraction values = 0.12). For example, the odds ratio for total breast cancer among women with =5 years between urine collection and diagnosis was 0.74 (Q4 vs. Q1; 95% CI: 0.45, 1.20; Ptrend = 0.09), and it was 1.20 (Q4 vs. Q1; 95% CI: 0.72, 1.98; Ptrend = 0.70) for women with >5 years. Our data do not support an overall association between urinary melatonin levels and breast cancer risk. [Description provided by NIOSH]
• Subjects:
  Aging Case Reports Energy Metabolism Epidemiology Neoplasms Occupational Health Safety Urine Women
• Keywords:
  6-sulfatoxymelatonin Age-groups Author Keywords: Breast Cancer Breast-cancer Cancer Case-studies Etiology Humans Melatonin Metabolites Urinalysis

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• ISSN:
  0002-9262
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  155-162
• Volume:
  181
• Issue:
  3
• NIOSHTIC Number:
  nn:20045969
• Citation:
  Am J Epidemiol 2015 Feb; 181(3):155-162
• Contact Point Address:
  Dr. Susan B. Brown, Division of Biostatistics and Epidemiology, University of Massachusetts, Amherst, 424 Arnold House, 715 North Pleasant Street, Amherst, MA 01003
• Email:
  snboyer@schoolph.umass.edu
• CAS Registry Number:
  Melatonin (CAS RN 73-31-4)
• Federal Fiscal Year:
  2015
• NORA Priority Area:
  Healthcare and Social Assistance
• Performing Organization:
  Brigham and Women's Hospital, Inc., Boston, Massachusetts
• Peer Reviewed:
  True
• Start Date:
  20100801
• Source Full Name:
  American Journal of Epidemiology
• End Date:
  20190831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:cd008b710c804e782e597f10d807e5732cae756b98f2a930d607c5410f4ad7224d6de638014e949275ef7dcc893dd4461a8d1d5e3d07f468003d40aa215f9df5
• Download URL:
  https://stacks.cdc.gov/view/cdc/201175/cdc_201175_DS1.pdf
• File Type:
  [PDF - 128.91 KB ]