Breast cancer incidence in a cohort of U.S. flight attendants

Details

• Personal Author:
  Anderson, Jeri L. ; Hein, Misty J. ; Little MP ; Pinkerton LE ; Schubauer-Berigan, Mary K. ; Sigurdson AJ
• Description:
  Background: Flight attendants may have elevated breast cancer incidence (BCI). We evaluated BCI's association with cosmic radiation dose and circadian rhythm disruption among 6,093 female former U.S. flight attendants. Methods: We collected questionnaire data on BCI and risk factors for breast cancer from 2002-2005. We conducted analyses to evaluate (i) BCI in the cohort compared to the U.S. population; and (ii) exposure-response relations. We applied an indirect adjustment to estimate whether parity and age at first birth (AFB) differences between the cohort and U.S. population could explain BCI that differed from expectation. Results: BCI was elevated but may be explained by lower parity and older AFB in the cohort than among U.S. women. BCI was not associated with exposure metrics in the cohort overall. Significant positive associations with both were observed only among women with parity of three or more. Conclusions: Future cohort analyses may be informative on the role of these occupational exposures and non-occupational risk factors. [Description provided by NIOSH]
• Subjects:
  Aircraft Circadian Rhythm Neoplasms Occupational Health Radiation Risk Assessment Risk Factors Safety Surveys And Questionnaires Women
• Keywords:
  Aircrews Author Keywords: Flight Crew Breast-cancer Cancer Circadian-rhythms Circadian Rhythm Disruption Cohort Studies Cosmic Humans Ionizing-radiation Ionizing Radiation Questionnaires Radiation-effects Radiation-exposure Risk-factors

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• ISSN:
  0271-3586
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; Ohio ; OSHA Region 3 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  252-266
• Volume:
  58
• Issue:
  3
• NIOSHTIC Number:
  nn:20045740
• Citation:
  Am J Ind Med 2015 Mar; 58(3):252-266
• Contact Point Address:
  Mary K. Schubauer-Berigan, PhD, National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations and Field Studies, Industrywide Studies Branch, Cincinnati, Ohio 45226
• Email:
  zcg3@cdc.gov
• Federal Fiscal Year:
  2015
• NORA Priority Area:
  Transportation, Warehousing and Utilities
• Peer Reviewed:
  True
• Source Full Name:
  American Journal of Industrial Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2a63da6862154852c6c0d02fcb894535195e201d89e5e0d1f9c4cd23583191c9f43171305724329f8e5b3c408ac8b31bb1d4a70572e65c5c51cbf71280162bad
• Download URL:
  https://stacks.cdc.gov/view/cdc/201040/cdc_201040_DS1.pdf
• File Type:
  [PDF - 512.81 KB ]