Endotoxin and gender modify lung function recovery after occupational organic dust exposure: a 30-year study

Details

• Personal Author:
  Brown D ; Christiani, David C. ; Eisen EA ; Hang J-Q ; Lai PS ; Mehta AJ ; Shi J ; Su L ; Valeri L ; Zhang F-Y ; Zheng B-Y
• Description:
  Objectives: The purpose of this study is to determine the trajectory of lung function change after exposure cessation to occupational organic dust exposure, and to identify factors that modify improvement. Methods: The Shanghai Textile Worker Study is a longitudinal study of 447 cotton workers exposed to endotoxin-containing dust and 472 silk workers exposed to non-endotoxin-containing dust. Spirometry was performed at 5-year intervals. Air sampling was performed to estimate individual cumulative exposures. The effect of work cessation on forced expiratory volume in 1 s (FEV1) was modelled using generalised additive mixed effects models to identify the trajectory of FEV1 recovery. Linear mixed effects models incorporating interaction terms were used to identify modifiers of FEV1 recovery. Loss to follow-up was accounted for with inverse probability of censoring weights. Results: 74.2% of the original cohort still alive participated in 2011. Generalised additive mixed models identified a non-linear improvement in FEV1 for all workers after exposure cessation, with no plateau noted 25 years after retirement. Linear mixed effects models incorporating interaction terms identified prior endotoxin exposure ( p=0.01) and male gender ( p=0.002) as risk factors for impaired FEV1 improvement after exposure cessation. After adjusting for gender, smoking delayed the onset of FEV1 gain but did not affect the overall magnitude of change. Conclusions: Lung function improvement after cessation of exposure to organic dust is sustained. Endotoxin exposure and male gender are risk factors for less FEV1 improvement. [Description provided by NIOSH]
• Subjects:
  Dust Endotoxins Environmental Monitoring Gossypium Lung Manufacturing And Industrial Facilities Occupational Health Respiratory Function Tests Respiratory System Safety Textile Industry

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• Keywords:
  Air Sampling Cotton Dust Cotton Mill Workers Longitudinal Study Lung Function Organic Dusts Spirometry Textile Workers
• ISSN:
  1351-0711
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Massachusetts ; OSHA Region 1 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  72
• Issue:
  8
• NIOSHTIC Number:
  nn:20045736
• Citation:
  Occup Environ Med 2015 Aug; 72(8):546-552
• Contact Point Address:
  Dr Peggy S Lai, Pulmonary and Critical Care Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
• Email:
  pslai@hsph.harvard.edu
• Federal Fiscal Year:
  2015
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  Harvard University
• Peer Reviewed:
  True
• Start Date:
  19870701
• Source Full Name:
  Occupational and Environmental Medicine
• End Date:
  20220831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9c2a7cd4b4c7743f8c993a16b1d8d8886e7ea9b37e8f1b9534443b92e85cce554e7e641859a9bdad6c54eba61b78668593dab6b687d9cc2e2976d22e572ba8a4
• Download URL:
  https://stacks.cdc.gov/view/cdc/201037/cdc_201037_DS1.pdf
• File Type:
  [PDF - 598.42 KB ]