Imaging phenotype of occupational endotoxin-related lung function decline

Details

• Personal Author:
  Christiani, David C. ; Hang J-q ; Lai PS ; Su L ; Sun J ; Washko GR ; Zhang F-y ; Zheng B-Y
• Description:
  Background: Although occupational exposures contribute to a significant proportion of obstructive lung disease, the phenotype of obstructive lung disease associated with work-related organic dust exposure independent of smoking remains poorly defined. Methods: The Shanghai Textile Worker Study is a longitudinal study of endotoxin-exposed cotton and endotoxin-unexposed silk workers initiated in 1981. Spirometry, occupational endotoxin exposure, and smoking habits were assessed at five year intervals. High-resolution computed tomography (CT) was performed in 464 retired workers in 2011, with quantitative lung densitometric and airway analysis. Results: Significant differences in all CT measures were noted across exposure groups. Occupational endotoxin exposure was associated with a -1.3 % decrease in % emphysema (LAAI-950), 3.3 hounsfield units increase in 15th percentile density, 18.1 gram increase in lung mass, and a 2.3% increase in wall area %. Current but not former smoking was associated with a similar CT phenotype. Changes in LAAI-950 were highly correlated with 15th percentile density (correlation -1.0). Lung mass was the only measure associated with FEV1 decline, with each 10 gram increase in lung mass associated with an additional loss of -6.1 mL of FEV1 (p=0.001) between 1981 and 2011. Conclusions: There are many similarities between the effect of occupational endotoxin exposure and tobacco smoke exposure on lung parenchyma and airway remodeling. The effects of occupational endotoxin exposure appear to persist even after exposure cessation. LAAI-950 may not be a reliable indicator of emphysema in subjects without spirometric impairment. Lung mass is a CT-based biomarker of accelerated lung function decline. [Description provided by NIOSH]
• Subjects:
  Dust Endotoxins Lung Occupational Health Respiratory Function Tests Respiratory System Safety Smoke Smokers Textile Industry Tobacco Products

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• Keywords:
  Cotton Dust Dust Exposure Imaging Techniques Longitudinal Study Lung Function Organic Dusts Smoking Spirometry Textiles Industry Tobacco Smoke
• ISSN:
  0091-6765
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  124
• Issue:
  9
• NIOSHTIC Number:
  nn:20047988
• Citation:
  Environ Health Perspect 2016 Sep; 124(9):1436-1442
• Contact Point Address:
  Peggy S. Lai, Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Bulfinch 148, 55 Fruit Street, Boston, MA 02114
• Email:
  pslai@hsph.harvard.edu
• Federal Fiscal Year:
  2016
• Performing Organization:
  Harvard University
• Peer Reviewed:
  True
• Start Date:
  19870701
• Source Full Name:
  Environmental Health Perspectives
• End Date:
  20220831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4e0e44eba1ea7ab95adf6388005a795f98d60925bce949efc907c15f69e8a4caebefd57558ae4eea712d09c1422e1254415d382cb25ed9847b71afb90cb1259a
• Download URL:
  https://stacks.cdc.gov/view/cdc/202885/cdc_202885_DS1.pdf
• File Type:
  [PDF - 410.57 KB ]