Health assessment of gasoline and fuel oxygenate vapors: neurotoxicity evaluation

Details

• Personal Author:
  Clark CR ; Daughtrey WC ; O'Callaghan JP ; Schreiner CA ; White R
• Description:
  Sprague-Dawley rats were exposed via inhalation to vapor condensates of either gasoline or gasoline combined with various fuel oxygenates to assess potential neurotoxicity of evaporative emissions. Test articles included vapor condensates prepared from "baseline gasoline" (BGVC), or gasoline combined with methyl tertiary butyl ether (G/MTBE), ethyl t-butyl ether (G/ETBE), t-amyl methyl ether (G/TAME), diisopropyl ether (G/DIPE), ethanol (G/EtOH), or t-butyl alcohol (G/TBA). Target concentrations were 0, 2000, 10,000 or 20,000 mg/mg3 and exposures were for 6 h/day, 5 days/week for 13 weeks. The functional observation battery (FOB) with the addition of motor activity (MA) testing, hematoxylin and eosin staining of brain tissue sections, and brain regional analysis of glial fibrillary acidic protein (GFAP) were used to assess behavioral changes, traditional neuropathology and astrogliosis, respectively. FOB and MA data for all agents, except G/TBA, were negative. G/TBA behavioral effects resolved during recovery. Neuropathology was negative for all groups. Analyses of GFAP revealed increases in multiplebrain regions largely limited to males of the G/EtOH group, findings indicative of minor gliosis, most significantly in the cerebellum. Small changes (both increases and decreases) in GFAP were observed for other test agents but effects were not consistent across sex, brain region or exposure concentration. [Description provided by NIOSH]
• Subjects:
  Animals Behavior Fuel Oils Laboratories Nervous System Nervous System Diseases Occupational Health Safety Solvents
• Keywords:
  Astrogliosis Author Keywords: Neurotoxicity Brain-damage Brain-function Diisopropyl Ether Emission-sources Ethanol Exposure-levels Fuels Gasoline Vapor Condensates Glial Fibrillary Acidic Protein (GFAP) Laboratory-animals Methyl-compounds MEthyl T-butyl Ether Methyl Tertiary Butyl Ether Neuropathology Neurotoxicity Proteins T-Amyl Methyl Ether T-Butyl Alcohol Vapors

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• ISSN:
  0273-2300
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  District of Columbia ; New Jersey ; Oklahoma ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 6 ; Pennsylvania ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  70
• Issue:
  2
• NIOSHTIC Number:
  nn:20045341
• Citation:
  Regul Toxicol Pharmacol 2014 Nov; 70(2)(Suppl):S35-S42
• Contact Point Address:
  Charles R. Clark, 5901 Woodland Road, Bartlesville, OK 74006
• Email:
  castox@comcast.net
• CAS Registry Number:
  Diisopropyl ether (CAS RN 108-20-3) ; Ethanol (CAS RN 64-17-5) ; Ethyl tert-butyl ether (CAS RN 637-92-3) ; tert-Amyl methyl ether (TAME) (CAS RN 994-05-8) ; tert-Butanol (CAS RN 75-65-0) ; tert-Butyl methyl ether (CAS RN 1634-04-4)
• Federal Fiscal Year:
  2015
• NORA Priority Area:
  Construction ; Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Regulatory Toxicology and Pharmacology
• Supplement:
  Suppl
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d5aa27d3dd02b7c30279b3d6be2df32ceeb9dda2f3b05bdf26b441c2ab416df772206eae4c3df0bc160e9fdc167a5c4d8794b185b08e1e829cc51d1de74dc4ee
• Download URL:
  https://stacks.cdc.gov/view/cdc/200798/cdc_200798_DS1.pdf
• File Type:
  [PDF - 438.58 KB ]