Insomnia in shift work disorder (SWD) associated with cortical excitability: an ERP study prior to a night shift

Details

• Personal Author:
  Drake C ; Gumenyuk V ; Howard R ; Roehrs T ; Roth T
• Description:
  Introduction: Hyperarousal as a characteristic of primary insomnia may be reflected in neuronal excitability of the central auditory system. Currently, it is unknown whether insomnia (INS) in the context of shift work (SWD-INS) is characterized by elevated amplitude of the N1 auditory brain response measured by event-related brain potentials (ERPs). Insomnia is also associated with cognitive processing deficits. This study examined the N1 as a measure of neuronal excitability and the MMN as a measure of cognitive processing in SWD-INS during the night. Methods: 5 night-workers with SWD-INS (38+/-10.3yrs. 1 male; ESS 7.8+/-1.2: ISI 15.5+/-3.9) and 9 asymptomatic night workers (ANW) (31.5+/-5.5yrs, 3 males; ESS 7.9+/-1.7: lSI 6.6+/-2.8) participated. All worked a 10-12hr shift between 19:00 and 08:00 and were free of other sleep disorders and otherwise healthy. The ERP session started at 18:00. The peak latency of N1 elicited by an infrequent sound (frequency deviant) was measured between 90-110 ms from sound onset. The MMN was elicited when the brain pre-attentively detected a frequency change in the sound-sequence and was measured between 130-160 ms from sound onset. Evaluation of sleepiness was performed by a standard MLST starting at 22:30. Results: Mean MSLT score from 22:30 - 02:30 was not significantly different between groups (9+/-5min [ANW] vs. 10+/-8min [SWD-INS]), but the ISI differed (15.5+/-3.9 [SWD-INS] vs. 6.6+/-2.8 [ANW] p<.02). The N1 amplitude was significantly elevated in SWD-INS relative to ANW (-1.7+/-O.8 microV vs. -1.1+/-0.6 microV, p<0.0 1). MMN was not significantly different between SWD-INS and ANW (-0.9 microV+/-0.8 microV vs. -1.0 microV+/-0.7microV). Conclusion: Cortical excitability is present in SWD-INS and can be objectively determined by the N1 brain response in the auditory modality. In the wake state, SWD-INS is not associated with a deficit of sensory memory. [Description provided by NIOSH]
• Subjects:
  Aging Men Mental Health Nervous System Noise Noise, Occupational Occupational Health Safety Sense Organs Shift Work Schedule Sleep Sleep Initiation And Maintenance Disorders

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• Keywords:
  Age-groups Auditory-system Brain-electrical-activity Brain-function Brain-matter Humans Mental-processes Nervous-system Physiological-response Sensory-perceptual-processes Shift-work Shift-workers Sleep-deprivation Sleep-disorders Sound Work-intervals

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• ISSN:
  0161-8105
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  Michigan ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  36
• NIOSHTIC Number:
  nn:20045335
• Citation:
  Sleep 2013 Jun; 36(Abstract Suppl):A199
• Contact Point Address:
  V. Gumenyuk, Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, MI, USA
• Federal Fiscal Year:
  2013
• Performing Organization:
  Henry Ford Health System, Detroit, Michigan
• Peer Reviewed:
  False
• Start Date:
  20110901
• Source Full Name:
  Sleep
• Supplement:
  Abstract Supplement
• End Date:
  20140831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:76089c9146947d8a7e582ecae5897e09143a5f2619e455e6452b5c00f51626ef8ecf70bbbc67ab37291f3245fa2e51d9d787b135c53e0ba70b0c90d253c6a6f6
• Download URL:
  https://stacks.cdc.gov/view/cdc/200792/cdc_200792_DS1.pdf
• File Type:
  [PDF - 587.21 KB ]