Cortical excitability in night workers with insomnia is attenuated following a night shift: an ERP study

Details

• Personal Author:
  Drake C ; Gumenyuk V ; Howard R ; Roehrs T ; Roth T
• Description:
  Introduction: We previously demonstrated that insomnia in SWD (SWD-INS) is associated with cortical neuronal excitability in the central auditory system, as reflected by enhanced amplitude of the N1 ERP brain response. In this study, we tested whether cortical excitability can be attenuated by 12h of nocturnal sleep deprivation (SD) in SWD-INS. Secondarily, we compared cognitive auditory processing as measured by MMN ERP component in SWD-INS relative to asymptomatic night-workers (ANW) at 18:00 and 06:00, (i.e. beginning and end of the night shift). Methods: 5 night workers with SWD-INS (38yrs+/-10.3yrs, 1 male: ESS 7.8+/-1.2; ISI 15.5+/-3.9) and 9 ANWs (31.5+/-5.5yrs, 3 males: ESS 7.9+/-1.7; ISI 6.6+/-2.8) participated in a baseline (BL) ERP session starting at 18:00 and a SD ERP session starting at 06:00 hours (SD). Between sessions, participants were kept awake in a dimly lit room (10 lux). The N1 brain response to frequency-deviant sounds was measured at a latency of 90-110 ms. The MMN (at a latency of 130-160 ms) was elicited when the brain pre-attentively detected a frequency change in the sound-sequence. Subjects were instructed to ignore all sounds. The peak amplitude of N1 and MMN at BL was compared to that during SD in each group. Results: Sleep deprivation significantly reduced N1 amplitude over the frontal-central electrode (Fz-Cz) in SWD-INS from BL (-1.6+/-0.7 microV) to SD (-0.7+/-0.6 microV, p<0.04). The attenuation of the MMN amplitude after SD was significant in SWD-INS (-0.5+/-0.6 microV) relative to that in BL (-1.0+/-0.8 microV, p<0.03). In ANW, the amplitude of N1 was not significantly different between BL (-1.1+/-0.6 microV) and SD (-1.0+/-0. 7 microV) across Fz/Cz electrodes. The amplitude of the MMN component was similar between BL (-1.0 microV+/-0.7 microV) and SD (-0.7 microV+/-0.9 microV) in ANW. Conclusion: Cortical excitability in SWD-INS is reduced with sleep deprivation during the night shift. Sensory processing in night workers with insomnia is impacted by sleep deprivation during the night shift. [Description provided by NIOSH]
• Subjects:
  Aging Men Nervous System Noise Noise, Occupational Occupational Health Safety Sense Organs Shift Work Schedule Sleep Sleep Initiation And Maintenance Disorders

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• Keywords:
  Age-groups Auditory-system Brain-electrical-activity Brain-function Brain-matter Humans Nervous-system Physiological-response Sensory-perceptual-processes Shift-work Shift-workers Sleep-deprivation Sleep-disorders Sound Work-intervals

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• ISSN:
  0161-8105
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  Michigan ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  36
• NIOSHTIC Number:
  nn:20045324
• Citation:
  Sleep 2013 Jun; 36(Abstract Suppl):A194
• Contact Point Address:
  V. Gumenyuk, Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, MI, USA
• Federal Fiscal Year:
  2013
• Performing Organization:
  Henry Ford Health System, Detroit, Michigan
• Peer Reviewed:
  False
• Start Date:
  20110901
• Source Full Name:
  Sleep
• Supplement:
  Abstract Supplement
• End Date:
  20140831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:075e55e2d251ba8093e5f9cbe4e397dbdf9db87f85074095e3957712876f471ede06c6aff7e7792fa0a49c4d2b7d224b38a034bbe72facdc86dfe06f796f4dbf
• Download URL:
  https://stacks.cdc.gov/view/cdc/200783/cdc_200783_DS1.pdf
• File Type:
  [PDF - 5.38 MB ]