Sleep loss, circadian mismatch, and abnormalities in reorienting of attention in night workers with shift work disorder

Details

• Personal Author:
  Drake CL ; Gumenyuk V ; Howard R ; Korzyukov O ; Roth T
• Description:
  STUDY OBJECTIVES: Permanent night-shift workers may develop shift-work disorder (SWD). In the current study, we evaluated neurophysiological and behavioral indices of distractibility across times prior to the night shift (T1), during night hours (T2), and after acute sleep deprivation (T3) in permanent hospital night workers with and without SWD. METHODS: Ten asymptomatic night workers (NW) and 18 NW with SWD participated in a 25-h sleep deprivation study. Circadian phase was evaluated by dim-light salivary melatonin onset (DLMO). Objective sleepiness was evaluated using the Multiple Sleep Latency Test (MSLT). Electrophysiological distractibility was evaluated by brain event-related potentials (ERP), whereas behavioral distractibility was evaluated by performance on a visual task in an auditory-visual distraction paradigm. STATISTICAL ANALYSES: Comparisons of ERP results were performed by repeated-measures analysis of variance, and t-tests were used where appropriate. A Mann-Whitney U test was used for comparison of variables (MLST, Stanford Sleepiness Scale, and DLMO) that deviated from normal. RESULTS: First, in the SWD group, the reorienting negativity ERP amplitude was significantly attenuated compared to that in the NW group. Second, the SWD group had shorter MSLT during night shift hours (4.8 +/- 4.9 min) compared to that in NW (7.8 +/- 3.7 min; U = 47; z = -2.1; P < 0.03). Third, NW with SWD had a DLMO at 20:27 +/- 5.0 h, whereas healthy NW had a DLMO at 05:00 +/- 3.4 h (U = 43.5; z = -2.22, P < 0.03). Finally, acute sleep deprivation impaired behavioral performance and the P3a ERP in both groups. CONCLUSIONS: Our results demonstrate specific deficits in neurophysiological activity in the attentional domain among the shift-work disorder group relative to night workers. [Description provided by NIOSH]
• Subjects:
  Behavior Circadian Rhythm Electrophysiology Energy Metabolism Health Personnel Men Nervous System Occupational Health Radiation Safety Shift Work Schedule Sleep Sleep Initiation And Maintenance Disorders Women

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• Keywords:
  Audio-visual-communication Author Keywords: Shift Work Disorder Behavioral-testing Brain-electrical-activity Brain-function Circadian-rhythms Circadian Phase Distractibility Electrophysiological-effects ERPs Health-care-personnel Humans Metabolism Neurophysiological-effects Physiology Physiopathology Radiation-effects Shift-work Shift-workers Sleep-deprivation Sleep-disorders Work-intervals Work-performance

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• ISSN:
  0161-8105
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Illinois ; Michigan ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  37
• Issue:
  3
• NIOSHTIC Number:
  nn:20045325
• Citation:
  Sleep 2014 Mar; 37(3):545-556
• Contact Point Address:
  Valentina Gumenyuk, PhD, Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, MI
• Email:
  vgumeny1@hfhs.org
• Federal Fiscal Year:
  2014
• Performing Organization:
  Henry Ford Health System, Detroit, Michigan
• Peer Reviewed:
  True
• Start Date:
  20110901
• Source Full Name:
  Sleep
• End Date:
  20140831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:47c7bccd11e14f0d8312b1a82ff7ef673797a4ba3167e1e0a6f503c7d8fa964674020b92184dc2e67b748fea8fd50634db02f1fc60f924fd88192ddf1583c40e
• Download URL:
  https://stacks.cdc.gov/view/cdc/200784/cdc_200784_DS1.pdf
• File Type:
  [PDF - 912.59 KB ]