Differential sleep, sleepiness, and neurophysiology in the insomnia phenotypes of shift work disorder

Details

• Personal Author:
  Belcher R ; Drake CL ; Gumenyuk V ; Roth T
• Description:
  STUDY OBJECTIVES: To characterize and compare insomnia symptoms within two common phenotypes of Shift Work Disorder. DESIGN: Observational laboratory and field study. SETTING: Hospital sleep center. PARTICIPANTS: 34 permanent night workers. Subjects were classified by Epworth Sleepiness Scale and Insomnia Severity Index into 3 subgroups: asymptomatic controls, alert insomniacs (AI), and sleepy insomniacs (SI). MEASUREMENTS: Sleep parameters were assessed by sleep diary. Circadian phase was evaluated by dim-light salivary melatonin onset (DLMO). Objective sleepiness was measured using the multiple sleep latency test (MSLT). Brain activity was measured using the N1 event-related potential (ERP). A tandem repeat in PER3 was genotyped from saliva DNA. RESULTS: (1) AI group showed normal MSLT scores but elevated N1 amplitudes indicating cortical hyperarousal. (2) SI group showed pathologically low MSLT scores but normal N1 amplitudes. (3) AI and SI groups were not significantly different from one another in circadian phase, while controls were significantly phase-delayed relative to both SWD groups. (4) AI showed significantly longer sleep latencies and lower sleep efficiency than controls during both nocturnal and diurnal sleep. SI significantly differed from controls in nocturnal sleep parameters, but differences during diurnal sleep periods were smaller and not statistically significant. (5) Genotype × phenotype ?² analysis showed significant differences in the PER3 VNTR: 9 of 10 shift workers reporting sleepiness in a post hoc genetic substudy were found to carry the long tandem repeat on PER3, while 4 of 14 shift workers without excessive sleepiness carried the long allele. CONCLUSIONS: Our results suggest that the sleepy insomnia phenotype is comprehensively explained by circadian misalignment, while the alert insomnia phenotype resembles an insomnia disorder precipitated by shift work. [Description provided by NIOSH]
• Subjects:
  Circadian Rhythm Genetics Men Nervous System Occupational Health Safety Shift Work Schedule Sleep Sleep Initiation And Maintenance Disorders Women
• Keywords:
  Author Keywords: Insomnia Brain-function Circadian-rhythms Circadian Phase ERPs Event-related Brain Potentials Humans Insomnia Severity Index ISI MSLT Multiple Sleep Latency Test Physiology Physiopathology Shift-work Shift-workers Shift Work Sleep-deprivation Sleep-disorders

  More +
• ISSN:
  0161-8105
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Illinois ; Michigan ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  119-126
• Volume:
  38
• Issue:
  1
• NIOSHTIC Number:
  nn:20046572
• Citation:
  Sleep 2015 Jan; 38(1):119-126
• Contact Point Address:
  Valentina Gumenyuk, PhD, Sleep Disorders and Research Center, Henry Ford Hospital, 2799 W. Grand Boulevard, CFP-3, Detroit, MI 48202
• Email:
  vgumeny1@hfhs.org
• Federal Fiscal Year:
  2015
• Performing Organization:
  Henry Ford Health System, Detroit, Michigan
• Peer Reviewed:
  True
• Start Date:
  20110901
• Source Full Name:
  Sleep
• End Date:
  20140831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:aa58ab9d0032e7316580c15ea968ca62f351de57f6328acea1cc39dad26488b2a5fbe9e8133e929811d3741a59c93a76038aa8e15be8335ad48da64e7c2179c2
• Download URL:
  https://stacks.cdc.gov/view/cdc/201585/cdc_201585_DS1.pdf
• File Type:
  [PDF - 546.38 KB ]