Dietary Potassium Oxonate Increases Uric Acid in Rat Plasma and Bronchoalveolar Lavage Fluid

Details

• Personal Author:
  Blemings KP ; Kain B ; Klandorf H ; Porter, Dale
• Description:
  Uric acid (VA) may be an important antioxidant, but its role in the lung has not been investigated. It is our hypothesis that by raising VA concentrations, silica-induced pulmonary damage may be ameliorated. In the first of a two part study, 52 male Sprague-Daley rats were randomized to four dietary treatments of 0, 2.5, 5.0, or 7.5% potassium oxonate (PO), an inhibitor of uricase. Four rats per group were sacrificed on days 10, 20, and 30. Plasma and bronchoalveolar lavage (BAL) fluid were analyzed for UA by HPLC. Dietary PO increased plasma (p0.0.5). The ability of dietary PO to increase VA levels, and its lack of non-specific toxicity, will be utilized in future studies designed to investigate the effect of increased VA levels on silica-induced pulmonary disease. [Description provided by NIOSH]
• Subjects:
  Aluminum Silicates Animals Antioxidants Laboratories Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety Silicon Dioxide

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• Keywords:
  Animal-studies Laboratory-animals Lung-disorders Pulmonary-disorders Pulmonary-function Pulmonary-system Pulmonary-system-disorders Silica-dusts Silicates
• ISSN:
  0892-6638
• Document Type:
  Text
• Genre:
  Abstract or Summary ; Proceedings
• Place as Subject:
  Louisiana ; OSHA Region 3 ; OSHA Region 6 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  16
• Issue:
  5
• NIOSHTIC Number:
  nn:20023064
• Citation:
  FASEB J 2002 Mar; 16(5):A963
• CAS Registry Number:
  Potassium (CAS RN 7440-09-7) ; Silica (CAS RN 7631-86-9)
• Federal Fiscal Year:
  2002
• Peer Reviewed:
  False
• Source Full Name:
  The FASEB Journal, Experimental Biology 2002, New Orleans, Louisiana, April 20-24, 2002
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a963283e8f03d10a2cd24e487be5e1c7896bed0bd7c9ad0820c642fee48b95c9c598cd354b6a259b38141bec0ed348489223b2f7d70037784ff008f4c2b932a3
• Download URL:
  https://stacks.cdc.gov/view/cdc/199648/cdc_199648_DS1.pdf
• File Type:
  [PDF - 146.23 KB ]