Incident ischemic heart disease and recent occupational exposure to particulate matter in an aluminum cohort

Details

• Personal Author:
  Brown DM ; Cantley L ; Costello S ; Cullen MR ; Eisen EA ; Hammond SK ; Noth EM ; Slade MD ; Tessier-Sherman B
• Description:
  Fine particulate matter (PM(2.5)) in air pollution, primarily from combustion sources, is recognized as an important risk factor for cardiovascular events but studies of workplace PM(2.5) exposure are rare. We conducted a prospective study of exposure to PM(2.5) and incidence of ischemic heart disease (IHD) in a cohort of 11,966 US aluminum workers. Incident IHD was identified from medical claims data from 1998 to 2008. Quantitative metrics were developed for recent exposure (within the last year) and cumulative exposure; however, we emphasize recent exposure in the absence of interpretable work histories before follow-up. IHD was modestly associated with recent PM(2.5) overall. In analysis restricted to recent exposures estimated with the highest confidence, the hazard ratio (HR) increased to 1.78 (95% CI: 1.02, 3.11) in the second quartile and remained elevated. When the analysis was stratified by work process, the HR rose monotonically to 1.5 in both smelter and fabrication facilities, though exposure was almost an order of magnitude higher in smelters. The differential exposure-response may be due to differences in exposure composition or healthy worker survivor effect. These results are consistent with the air pollution and cigarette smoke literature; recent exposure to PM(2.5) in the workplace appears to increase the risk of IHD incidence. [Description provided by NIOSH]
• Subjects:
  Aluminum Compounds Cardiovascular Diseases Cardiovascular System Cohort Studies Epidemiology Metals Metal Workers Occupational Exposure Occupational Health Particulate Matter Safety

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• Keywords:
  Aluminum Industry Author Keywords: Occupational Epidemiology Cardiovascular Disease Cohort Studies Heart Disease Occupational Exposure Particulate Matter Particulates Smelters
• ISSN:
  1559-0631
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Connecticut ; OSHA Region 1 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  82-88
• Volume:
  24
• Issue:
  1
• NIOSHTIC Number:
  nn:20044862
• Citation:
  J Expo Sci Environ Epidemiol 2014 Jan-Feb; 24(1):82-88
• Contact Point Address:
  Dr. Sadie Costello, Environmental Health Science, School of Public Health, University of California, 789 University Hall, Berkeley, CA 94703, USA
• Email:
  sadie@berkeley.edu
• Federal Fiscal Year:
  2014
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  Stanford University
• Peer Reviewed:
  True
• Start Date:
  20110901
• Source Full Name:
  Journal of Exposure Science and Environmental Epidemiology
• End Date:
  20200831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:bbca498318cd81225dda5fcabc0e2a63c65c47702f553fc33fb6cae9c7b943bfc17e4b53bcc4209e360c62d269357713fd505d84780b6b954e64abfe229fc3f8
• Download URL:
  https://stacks.cdc.gov/view/cdc/200472/cdc_200472_DS1.pdf
• File Type:
  [PDF - 419.28 KB ]