A sensitive LC-MS/MS method for measurement of organophosphorus pesticides and their oxygen analogs in air sampling matrices

Details

• Personal Author:
  Armstrong, Jenna L. ; Dills RL ; Fenske RA ; Yost MG ; Yu J
• Description:
  A rapid liquid chromatography tandem mass spectrometry (LC-MS/MS) method has been developed for determination of levels of the organophosphorus (OP) pesticides chlorpyrifos (CPF), azinphos methyl (AZM), and their oxygen analogs chlorpyrifos-oxon (CPF-O) and azinphos methyl-oxon (AZM-O) on common active air sampling matrices. XAD-2 resin and polyurethane foam (PUF) matrices were extracted with acetonitrile containing stable-isotope labeled internal standards (ISTD). Analysis was accomplished in Multiple Reaction Monitoring (MRM) mode, and analytes in unknown samples were identified by retention time (+/-0.1 min) and qualifier ratio (+/-30% absolute) as compared to the mean of calibrants. For all compounds, calibration linearity correlation coefficients were =0.996. Limits of detection (LOD) ranged from 0.15-1.1 ng/sample for CPF, CPF-O, AZM, and AZM-O on active sampling matrices. Spiked fortification recoveries were 78-113% from XAD-2 active air sampling tubes and 71-108% from PUF active air sampling tubes. Storage stability tests also yielded recoveries ranging from 74-94% after time periods ranging from 2-10 months. The results demonstrate that LC-MS/MS is a sensitive method for determining these compounds from two different matrices at the low concentrations that can result from spray drift and long range transport in non-target areas following agricultural applications. In an inter-laboratory comparison, the limit of quantification (LOQ) for LC-MS/MS was 100 times lower than a typical gas chromatography-mass spectrometry (GC-MS) method. [Description provided by NIOSH]
• Subjects:
  Agriculture Environmental Monitoring Epoxy Resins Occupational Health Polyurethanes Safety
• Keywords:
  Agricultural-chemicals Air-sampling Analytical-methods Author Keywords: Air Monitoring Drift Monitoring-systems Organophosphorus Organophosphorus-pesticides Oxon Pesticide Polyurethane-foams Polyurethane Foam Resins XAD Resin

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• ISSN:
  0360-1234
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 10 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  102-108
• Volume:
  49
• Issue:
  2
• NIOSHTIC Number:
  nn:20044807
• Citation:
  J Environ Sci Health, Part B, Pestic Food Contam Agric 2014 Feb; 49(2):102-108
• Contact Point Address:
  Jenna L. Armstrong, Department of Environmental and Occupational Health Sciences, University of Washington School of Public Health, box 357234, Seattle, WA 98195
• Email:
  jennaa@uw.edu
• Federal Fiscal Year:
  2014
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20010930
• Source Full Name:
  Journal of Environmental Science and Health. Part B: Pesticides, Food Contaminants, and Agricultural Wastes
• End Date:
  20270929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9c4dd5919d729eb552cf3ffe387e98ea5d6d76c66526d0df7c2df1e30523ec60e0aeb4926cdc65199c7d79b28b58f6ac574eb8ab8d837b81a1267afb4b95f9ee
• Download URL:
  https://stacks.cdc.gov/view/cdc/200432/cdc_200432_DS1.pdf
• File Type:
  [PDF - 480.91 KB ]