Prenatal exposure to dichlorodiphenyltrichloroethane and obesity at 9 years of age in the CHAMACOS study cohort

Details

• Personal Author:
  Bradman A ; Eskenazi B ; Harley KG ; Kogut K ; Warner M ; Wesselink A
• Description:
  In-utero exposure to endocrine-disrupting compounds, including dichlorodiphenyltrichloroethane (DDT) and its metabolite dichlorodiphenylethylene (DDE), has been hypothesized to increase the risk of obesity later in life. We examined the associations of maternal serum concentrations of DDT and DDE during pregnancy with body mass index, obesity, waist circumference, and percentage of body fat in 9-year-old children (n = 261) in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) Study, a longitudinal birth cohort study in the Salinas Valley, California (2000-2010). We found associations between prenatal exposure to DDT and DDE and several measures of obesity at 9 years of age in boys but not in girls. For example, among boys, 10-fold increases in prenatal DDT and DDE concentrations were associated with increased odds of becoming overweight or obese (for o,p'-DDT, adjusted odds ratio (OR) = 2.5, 95% confidence interval (CI): 1.0, 6.3; for p,p'-DDT, adjusted OR = 2.1, 95% CI: 1.0, 4.5; and for p,p'-DDE, adjusted OR = 1.97, 95% CI: 0.94, 4.13). The odds ratios for girls were nonsignificant. Results were similar for body mass index z score, waist circumference z score, and odds of increased waist circumference but were less consistent for percentage of body fat. The difference by sex persisted after considering pubertal status. These results provide support for the chemical obesogen hypothesis. [Description provided by NIOSH]
• Subjects:
  Adolescent Biomarkers Blood Chemistry Environmental Exposure Environmental Pollution Hazardous Substances Hematologic Tests Men Occupational Health Pregnancy Risk Assessment Risk Factors Safety Sex Characteristics Women

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• Keywords:
  Adolescents Blood-samples Chemical-composition Children Drugs Environmental-pollution Exposure-limits Humans In-utero-exposure Models Monitoring-systems Monitors Prenatal-exposure Risk-factors Sex-factors Toxic-effects Weight-factors

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• ISSN:
  0002-9262
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  179
• Issue:
  11
• NIOSHTIC Number:
  nn:20044733
• Citation:
  Am J Epidemiol 2014 Jun; 179(11):1312-1322
• Contact Point Address:
  Dr. Marcella Warner, Center for Environmental Research and Children's Health, School of Public Health, University of California, 1995 University Avenue, Suite 265, Berkeley, CA 94720-7392
• Email:
  mwarner@berkeley.edu
• CAS Registry Number:
  DDT (CAS RN 50-29-3) ; p,p′-DDE (CAS RN 72-55-9)
• Federal Fiscal Year:
  2014
• Performing Organization:
  University of California, Berkeley
• Peer Reviewed:
  True
• Start Date:
  20010930
• Source Full Name:
  American Journal of Epidemiology
• End Date:
  20060929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:64329cf3352404e11cbbc238ac3385441e4ba03c578605d414b28b35d954d8445f97d482173e0592225536510e36e5cf01570ec2ae0fb7f4ad017ae7ef0698ba
• Download URL:
  https://stacks.cdc.gov/view/cdc/200371/cdc_200371_DS1.pdf
• File Type:
  [PDF - 174.85 KB ]