A pilot case-cohort study of brain cancer in poultry and control workers

Details

• Personal Author:
  Cardarelli K ; Faramawi M ; Felini MJ ; Gandhi S ; Jadhav S ; Johnson ES ; Ndetan H
• Description:
  We conducted an exploratory study to investigate which exposures (including poultry oncogenic viruses) are associated with brain cancer in poultry workers. A total of 46,819 workers in poultry and nonpoultry plants from the same union were initially followed for mortality. Brain cancer was observed to be in excess among poultry workers. Here we report on a pilot case-cohort study with cases consisting of 26 (55%) of the 47 brain cancer deaths recorded in the cohort, and controls consisting of a random sample of the cohort (n = 124). Exposure information was obtained from telephone interviews, and brain cancer mortality risk estimated by odds ratios. Increased risk of brain cancer was associated with killing chickens, odds ratio (OR) = 5.8 (95% confidence interval, 1.2-28.3); working in a shell-fish farm, OR = 13.0 (95% CI, 1.9-84.2); and eating uncooked fish, OR = 8.2 (95% CI, 1.8-37.0). Decreased risks were observed for chicken pox illness, OR = 0.2 (95% CI, 0.1-0.6), and measles vaccination, OR = 0.2 (95% CI, 0.1-0.6). Killing chickens, an activity associated with the highest occupational exposure to poultry oncogenic viruses, was associated with brain cancer mortality, as were occupational and dietary shellfish exposures. These findings are novel. [Description provided by NIOSH]
• Subjects:
  Animals Food-Processing Industry Food Industry Men Morbidity Mortality Neoplasms Nervous System Occupational Health Risk Assessment Risk Factors Safety Viral Diseases Women

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• Keywords:
  Brain-function Cancer Exposure-levels Food-processing-industry Food-processing-workers Humans Morbidity-rates Mortality-rates Pathogenicity Poultry Poultry-industry Poultry-workers Risk-factors Statistical-analysis Viral-diseases Viral-infections

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• ISSN:
  0163-5581
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Arkansas ; OSHA Region 6 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  343-350
• Volume:
  66
• Issue:
  3
• NIOSHTIC Number:
  nn:20046258
• Citation:
  Nutr Cancer 2014 Feb; 66(3):343-350
• Contact Point Address:
  E. S. Johnson, Department of Epidemiology, College of Public Health, University of Arkansas for Medical Sciences, 4301 W. Markham St., Little Rock, AR 72205
• Email:
  esjohnson@uams.edu
• Federal Fiscal Year:
  2014
• Performing Organization:
  University of North Texas
• Peer Reviewed:
  True
• Start Date:
  20050901
• Source Full Name:
  Nutrition and Cancer
• End Date:
  20080430
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:bde6f6df3367a7db4a2404849d12f9c14c9c25f688d2765b5ca74ff23f77897ecae444b2cf4213115ce6ed7881c72d1f83fe6ade6fe202b4e0e880e28f46407c
• Download URL:
  https://stacks.cdc.gov/view/cdc/201365/cdc_201365_DS1.pdf
• File Type:
  [PDF - 5.00 MB ]