Airflow and deposition of nano-particles in a human nasal cavity

Details

• Personal Author:
  Ahmadi G ; Cheng Y-S ; Hopke PK ; Leonard D ; Su WC ; Wang Z ; Zamankhan P
• Description:
  A 3D computational model was developed to study the flow and the transport and deposition of nano-size particle in a realistic human nasal passage. The nasal cavity was constructed from a series of MRI images of coronal sections of a nose of a live human subject. For several breathing rates associated with low or moderate activities, the steady state flows in the nasal passage were simulated numerically. The airflow simulation results were compared with the available experimental data for the nasal passage. Despite the anatomical differences of the human subjects used in the experiments and computer model, the simulation results were in qualitative agreement with the experimental data. Deposition and transport of ultrafine particles (1 to 100 nm) in the nasal cavity for different breathing rates were also simulated using an Eulerian-Lagrangian approach. The simulation results for the nasal capture efficiency were found to be in reasonable agreement with the available experimental data for a number of human subjects given typical anatomical differences. The computational results for the nasal capture efficiency for nano-particles and various breathing rates in the laminar regime were found to correlate well with the ratio of particle diffusivity to the breathing rate especially for the particles smaller than 20 nm. Based on the simulated results, a semi-empirical equation for the capture efficiency of the nasal passage for nano-size particles was fitted in terms of Peclet number. [Description provided by NIOSH]
• Subjects:
  Aerosols Air Movements Air Pollutants, Occupational Asbestos Computers Dust Environmental Monitoring Inhalation Exposure Inorganic Chemicals Nose Occupational Health Particulate Matter Risk Assessment Risk Factors Safety Sense Organs Software

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• Keywords:
  Aerosol-particles Air-flow Air-sampling Airborne-fibers Analytical-processes Asbestos-dust Asbestos-fibers Computer-models Computer-software Exposure-levels Fibrous-dusts Inhalants Models Nasal-cavity Particulates Risk-factors Simulation-methods

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• ISSN:
  0278-6826
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New Mexico ; New York ; OSHA Region 2 ; OSHA Region 6
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  463-476
• Volume:
  40
• Issue:
  6
• NIOSHTIC Number:
  nn:20044482
• Citation:
  Aerosol Sci Technol 2006 Jun; 40(6):463-476
• Contact Point Address:
  Goodarz Ahmadi, Department of Mechanical and Aeronautical Engineering, Potsdam, New York 13699-5725, USA
• Email:
  ahmadi@clarkson.edu
• Federal Fiscal Year:
  2006
• Performing Organization:
  Lovelace Biomedical & Environmental Research, Albuquerque, New Mexico
• Peer Reviewed:
  True
• Start Date:
  20020901
• Source Full Name:
  Aerosol Science and Technology
• End Date:
  20080831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:73664792457741de59720c9405eef06a4034deb194bbbc37e0b3100bc322a5b00c94364a266475b3793c4dde91c22acc41e10c324e0d4761a6ffb2e13beed852
• Download URL:
  https://stacks.cdc.gov/view/cdc/200172/cdc_200172_DS1.pdf
• File Type:
  [PDF - 772.22 KB ]