Serum cotinine levels and prehypertension in never smokers

Details

• Personal Author:
  Alshaarawy O ; Andrew, Michael E. ; Burchfiel C ; Shankar A ; Xiao J
• Description:
  Background. Few studies have shown that self-reported secondhand smoke exposure in never smokers is associated with high blood pressure. However, there are no studies investigating the relationship between secondhand smoke exposure, measured objectively by serum cotinine levels, and high blood pressure in never smokers. Methods. We examined never smokers (.. = 2027) from the National Health and Nutrition Examination Survey 2005.2008. Our exposure of interest was the secondhand smoke exposure estimated by serum cotinine level and our outcome was prehypertension (.. = 734), defined as a systolic blood pressure of 120. 139mmHg or diastolic blood pressure of 80.89mmHg. Results. We found that, in never smokers, serum cotinine levels were positively associated with prehypertension. Compared to those with cotinine levels in the lowest quartile (.0.024 ng/mL), the multivariable odds ratio (95% confidence interval) of prehypertension among those with cotinine levels in the highest quartile (.0.224 ng/mL) was 1.45(1.00, 2.11); .. trend = 0.0451. In subsequent subgroup analyses, the positive association was found to be stronger among men, non-Whites, and non-obese subjects. Conclusion. Higher secondhand smoke exposure measured objectively by serumcotinine levels was found to be associated with prehypertension in certain subgroups of a representative sample of the US population. [Description provided by NIOSH]
• Subjects:
  Blood Cardiovascular Diseases Cardiovascular System Lung Men Occupational Health Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety Smoke Smokers Women

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• Keywords:
  Blood-pressure Cardiopulmonary-system Cardiopulmonary-system-disorders Cardiovascular-disease Cardiovascular-system-disease Cardiovascular-system-disorders Exposure-levels Humans Hypertension Pulmonary-system Pulmonary-system-disorders Respiratory-system-disorders Risk-factors Smoke-inhalation Smoking

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• ISSN:
  2090-0392
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  2013
• NIOSHTIC Number:
  nn:20042806
• Citation:
  Int J Hypertens 2013 Feb; 2013:284524
• Email:
  anoopshankar@yahoo.com
• Federal Fiscal Year:
  2013
• Peer Reviewed:
  True
• Source Full Name:
  International Journal of Hypertension
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4b686615999d4893c8a770721cbc20b40466509d88e4941d00d77bc31d72adcf2dceb76f21ed5fc34369a6bb8210126688ba1b3eeb2c5efcba9b9c5e55801260
• Download URL:
  https://stacks.cdc.gov/view/cdc/194912/cdc_194912_DS1.pdf
• File Type:
  [PDF - 1.59 MB ]