Maternal occupational exposure to polycyclic aromatic hydrocarbons and small for gestational age offspring

Details

• Personal Author:
  Desrosiers TA ; Gilboa SM ; Hoyt AT ; Langlois PH ; Lawson, Christina C. ; Lupo PJ ; Malik S ; Rocheleau CM ; Romitti PA ; Shaw GM ; Waters MA
• Corporate Authors:
  National Birth Defects Prevention Network
• Description:
  Objectives: While some of the highest maternal exposures to polycyclic aromatic hydrocarbons (PAHs) occur in the workplace, there is only one previous study of occupational PAH exposure and adverse pregnancy outcomes. We sought to extend this literature using interview data combined with detailed exposure assessment. Methods: Data for 1997-2002 were analysed from mothers of infants without major birth defects in the National Birth Defects Prevention Study, a large population-based case-control study in the USA. Maternal telephone interviews yielded information on jobs held in the month before conception through delivery. From 6252 eligible control mothers, 2803 completed the interview, had a job, met other selection criteria, and were included in the analysis. Two industrial hygienists independently assessed occupational exposure to PAHs from the interview and reviewed results with a third to reach consensus. Small for gestational age (SGA) was the only adverse pregnancy outcome with enough exposed cases to yield meaningful results. Logistic regression estimated crude and adjusted ORs. Results: Of the 2803 mothers, 221 (7.9%) had infants who were SGA. Occupational PAH exposure was found for 17 (7.7%) of the mothers with SGA offspring and 102 (4.0%) of the remaining mothers. Almost half the jobs with exposure were related to food preparation and serving. After adjustment for maternal age, there was a significant association of occupational exposure with SGA (OR=2.2, 95% CI 1.3 to 3.8). Conclusions: Maternal occupational exposure to PAHs was found to be associated with increased risk of SGA offspring. [Description provided by NIOSH]
• Subjects:
  Case Reports Environmental Monitoring Food-Processing Industry Food Handling Food Industry Hydrocarbons Occupational Exposure Occupational Health Polycyclic Aromatic Hydrocarbons Pregnancy Risk Assessment Risk Factors Safety Surveys And Questionnaires Urogenital Diseases Urogenital System Women

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• Keywords:
  Birth-defects Case-studies Children Employee-exposure Exposure-assessment Food-processing-workers Food-services Health-surveys Humans Occupational-exposure Polycyclic-aromatic-hydrocarbons Prenatal-exposure Reproductive-effects Reproductive-hazards Risk-factors

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• ISSN:
  1351-0711
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Journal Article
• Place as Subject:
  Arkansas ; California ; Georgia ; Iowa ; North Carolina ; Ohio ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 6 ; OSHA Region 7 ; OSHA Region 9 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  71
• Issue:
  8
• NIOSHTIC Number:
  nn:20044435
• Citation:
  Occup Environ Med 2014 Aug; 71(8):529-535
• Contact Point Address:
  Dr. Peter H Langlois, Texas Center for Birth Defects Research and Prevention, Texas Department of State Health Services, PO Box 149347, MC 1964, Austin, TX 78714-9347, USA
• Email:
  peter.langlois@dshs.state.tx.us
• Federal Fiscal Year:
  2014
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  Battelle
• Peer Reviewed:
  True
• Start Date:
  20011001
• Source Full Name:
  Occupational and Environmental Medicine
• End Date:
  20060630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:bc6eadd91e62cb4f5af5491c7a1881adea8b0a171bbae0bef2a497048fe84946fbfdcd1b41e7e619f795e24bfe16ee0f1f4aefbb8c274513e47b8cfc593f9255
• Download URL:
  https://stacks.cdc.gov/view/cdc/200135/cdc_200135_DS1.pdf
• File Type:
  [PDF - 252.27 KB ]