Maternal occupational exposure to polycyclic aromatic hydrocarbons and risk of oral cleft-affected pregnancies

Details

• Personal Author:
  Desrosiers TA ; Hoyt AT ; Lammer EJ ; Langlois PH ; Lawson, Christina C. ; Lupo PJ ; Romitti PA ; Shaw GM ; Waters MA
• Description:
  Objective:To evaluate whether there is an association between maternal occupational exposure to polycyclic aromatic hydrocarbons and oral clefts in offspring. This is the first human study of polycyclic aromatic hydrocarbons and clefts of which the authors are aware. Design: Case-control study. Setting, Participants: Data for 1997 to 2002 from the National Birth Defects Prevention Study, a large population-based case-control study in the United States, were analyzed. Maternal telephone interviews yielded information on jobs held in the month before through 3 months after conception. Two industrial hygienists independently assessed occupational exposure to polycyclic aromatic hydrocarbons; all jobs rated as exposed or with rating difficulty were reviewed with a third industrial hygienist to reach consensus on all exposure parameters. Logistic regression estimated crude and adjusted odds ratios with 95% confidence intervals for cleft lip with or without cleft palate and cleft palate alone. Results : There were 2989 controls (3.5% exposed), 805 cases of cleft lip with or without cleft palate (5.8% exposed), and 439 cases of cleft palate alone (4.6% exposed). The odds of maternal occupational exposure to polycyclic aromatic hydrocarbons (any versus none) during pregnancy was increased for cleft lip with or without cleft palate cases as compared with controls (odds ratio, 1.69; 95% confidence interval, 1.18 to 2.40); the odds ratio was 1.47 (95% confidence interval 1.02 to 2.12) when adjusted for maternal education. There was a statistically significant adjusted exposure-response relationship for cleft lip with or without cleft palate (Ptrend = .02). Odd ratios for cleft palate alone were not statistically significant. Conclusions: Maternal occupational exposure to polycyclic aromatic hydrocarbons was associated with increased risk of cleft lip with or without cleft palate in offspring. [Description provided by NIOSH]
• Subjects:
  Case Reports Environmental Monitoring Hydrocarbons Occupational Exposure Occupational Health Polycyclic Aromatic Hydrocarbons Pregnancy Risk Assessment Risk Factors Safety Urogenital Diseases Urogenital System Women

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• Keywords:
  Author Keywords: Malformations Birth-defects Case-studies Children Dose-response Employee-exposure Exposure-assessment Humans Occupation Occupational-exposure Oral-cavity Oral-disorders PAHs Polycyclic-aromatic-hydrocarbons Polycyclic Aromatic Hydrocarbons Prenatal-exposure Reproductive-effects Reproductive-hazards Risk-factors Statistical-analysis

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• ISSN:
  1055-6656
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Journal Article
• Place as Subject:
  California ; Iowa ; North Carolina ; Ohio ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 6 ; OSHA Region 7 ; OSHA Region 9 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  337-346
• Volume:
  50
• Issue:
  3
• NIOSHTIC Number:
  nn:20042461
• Citation:
  Cleft Palate Craniofac J 2013 May; 50(3):337-346
• Contact Point Address:
  Dr. Peter Langlois, Texas Center for Birth Defects Research and Prevention, Texas Department of State Health Services, PO Box 149347, MC 1964, Austin, TX 78714-9347
• Email:
  peter.langlois@dshs.state.tx.us
• Federal Fiscal Year:
  2013
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  Battelle
• Peer Reviewed:
  True
• Start Date:
  20011001
• Source Full Name:
  The Cleft Palate-Craniofacial Journal
• End Date:
  20060630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:74454f752ea0cc817ec3dc6bd195cda9907f0064679ddfb32336dbd4800f3649bcb5c9aff28dc7ddf32eb094c0984be47f5978ccadbb9a6f29e7a9a7fe368898
• Download URL:
  https://stacks.cdc.gov/view/cdc/194683/cdc_194683_DS1.pdf
• File Type:
  [PDF - 254.20 KB ]