Cadmium and peripheral arterial disease: gender differences in the 1999-2004 US National Health and Nutrition Examination Survey

Details

• Personal Author:
  Crainiceanu CM ; Guallar E ; Navas-Acien A ; Sharrett AR ; Tellez-Plaza M
• Description:
  Gender differences in the association of blood and urine cadmium concentrations with peripheral arterial disease (PAD) were evaluated by using data from 6,456 US adults aged >/= 40 years who participated in the 1999-2004 National Health and Nutrition Examination Survey. PAD was defined as an ankle-brachial blood pressure index of <0.9 in at least one leg. For men, the adjusted odds ratios for PAD comparing the highest with the lowest quintiles of blood and urine cadmium concentrations were 1.82 (95% confidence interval (CI): 0.82, 4.05) and 4.90 (95% CI: 1.55, 15.54), respectively, with a progressive dose-response relation and no difference by smoking status. For women, the corresponding odds ratios were 1.19 (95% CI: 0.66, 2.16) and 0.56 (95% CI: 0.18, 1.71), but there was evidence of effect modification by smoking: among women ever smokers, there was a positive, progressive dose-response relation; among women never smokers, there was a U-shaped dose-response relation. Higher blood and urine cadmium levels were associated with increased prevalence of PAD, but women never smokers showed a U-shaped relation with increased prevalence of PAD at very low cadmium levels. These findings add to the concern of increased cadmium exposure as a cardiovascular risk factor in the general population. [Description provided by NIOSH]
• Subjects:
  Blood Cadmium Cardiovascular Diseases Cardiovascular System Epidemiology Metals Occupational Health Safety Surveys And Questionnaires Urine
• Keywords:
  Author Keywords: Cadmium Blood Vessels Cardiovascular Disease Health Surveys Peripheral Vascular Diseases Sex Characteristics Urinalysis
• ISSN:
  0002-9262
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  172
• Issue:
  6
• NIOSHTIC Number:
  nn:20044304
• Citation:
  Am J Epidemiol 2010 Sep; 172(6):671-681
• Contact Point Address:
  Dr. Ana Navas-Acien, Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Room W7033B, Baltimore, MD 21205
• Email:
  anavas@jhsph.edu
• CAS Registry Number:
  Arsenic (CAS RN 7440-38-2)
• Federal Fiscal Year:
  2010
• Performing Organization:
  Johns Hopkins University
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  American Journal of Epidemiology
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6120ea2a259449370381260c4c6f7ab5db18ae281502946b05bd289c5d586ef9eafa1eaebd033b5ed5e3268436fc8a12796a36d71b3f731b2636f442ce0bcc12
• Download URL:
  https://stacks.cdc.gov/view/cdc/200039/cdc_200039_DS1.pdf
• File Type:
  [PDF - 214.76 KB ]