Cadmium exposure and human health effects.

Details

• Personal Author:
  Creason JP ; Finklea, John F. ; Hammer DI ; Keil JE ; Priester LE ; Sandifer SH ; Stara JF
• Description:
  Several sensitive biologic response indicators are studied in 94 Black male workers exposed to a 0.02 percent cadmium (7440439) dust while producing superphosphate fertilizer. Cadmium and zinc (7440666) in plasma, but not in urine are found to be equally elevated in both the intermediate and high exposure groups. Systolic and diastolic blood pressures increase with age as expected, but inconsistently follow the exposure gradient. Cholesterol (57885) levels also show a strong expected relationship to age, but are not consistently related to exposure. Hemoglobin and hematocrit are unrelated to exposure. The data are taken to argue against a strong causal association between cadmium exposure and these cardiovascular disease risk indices. Previous studies linking cadmium to human hypertension and cardiovascular disease is considered tenuous and unconvincing. Autopsy studies demonstrating increased renal cadmium in patients dying with hypertension are shown to be confounded. It is suggested that studying continuous physiologic parameters rather than categorical disease classifications or end stage morbidity or mortality is a more sensitive method of detecting early effects of cadmium or other toxic substances. [Description provided by NIOSH]
• Subjects:
  Blood Cadmium Cardiovascular Diseases Cardiovascular System Epidemiology Hematologic Tests Metals, Heavy Nervous System Diseases Occupational Health Safety Urine

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• Keywords:
  Heavy-metals; Blood-chemistry; Epidemiology; Cardiovascular-system-disorders; Nervous-system-disorders; Measurement-methods; Etiology; Circulatory-system-disorders; Urine-chemistry; Cadmium; Detection
• Publisher:
  University of Missouri
• Document Type:
  Text
• Genre:
  Proceedings
• Place as Subject:
  Missouri ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  269-283
• NIOSHTIC Number:
  nn:00069241
• Citation:
  Trace Substances in Environmental Health - V. 1972; :269-283
• CAS Registry Number:
  Cadmium (CAS RN 7440-43-9) ; Cholesterol (CAS RN 57-88-5) ; Zinc (CAS RN 7440-66-6)
• Editor(s):
  Hemphill DD
• Federal Fiscal Year:
  1972
• Peer Reviewed:
  False
• Source Full Name:
  Trace Substances in Environmental Health - V
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/242056/cdc_242056_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]