Protein nanoparticles as drug delivery carriers for cancer therapy

Details

• Personal Author:
  Chen YC ; Lohcharoenkal W ; Rojanasakul Y ; Wang L
• Description:
  Nanoparticles have increasingly been used for a variety of applications, most notably for the delivery of therapeutic and diagnostic agents. A large number of nanoparticle drug delivery systems have been developed for cancer treatment and various materials have been explored as drug delivery agents to improve the therapeutic efficacy and safety of anticancer drugs. Natural biomolecules such as proteins are an attractive alternative to synthetic polymers which are commonly used in drug formulations because of their safety. In general, protein nanoparticles offer a number of advantages including biocompatibility and biodegradability.They can be prepared under mild conditions without the use of toxic chemicals or organic solvents. Moreover, due to their defined primary structure, protein-based nanoparticles offer various possibilities for surface modifications including covalent attachment of drugs and targeting ligands. In this paper, we review the most significant advancements in protein nanoparticle technology and their use in drug delivery arena. We then examine the various sources of protein materials that have been used successfully for the construction of protein nanoparticles as well as their methods of preparation. Finally, we discuss the applications of protein nanoparticles in cancer therapy. [Description provided by NIOSH]
• Subjects:
  Microbiology Neoplasms Occupational Health Particulate Matter Polymers Safety Solvents
• Keywords:
  Cancer Drugs Medical-treatment Nanotechnology Organic-solvents Particulates Proteins Therapeutic-agents
• ISSN:
  2314-6133
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  2014
• NIOSHTIC Number:
  nn:20044210
• Citation:
  Biomed Res Int 2014 Mar; 2014:180549
• Contact Point Address:
  Yon Rojanasakul, Mary Babb Randolph Cancer Center,West Virginia University, Morgantown,WV 26506
• Email:
  yrojan@hsc.wvu.edu
• Federal Fiscal Year:
  2014
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  BioMed Research International
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c0ae6ff9bdc9204278054a2ec6e1c7f2a8c67f8d732602e00d4afb3f9712202f4b176a0c5371a451f7c87ee409e95e34710db19980245bafaac68c091734b9c5
• Download URL:
  https://stacks.cdc.gov/view/cdc/199976/cdc_199976_DS1.pdf
• File Type:
  [PDF - 1.39 MB ]