Genetic variants in the major histocompatibility complex class I and class II genes are associated with diisocyanate-induced asthma

Details

• Personal Author:
  Bannerman-Thompson H ; Bernstein DI ; Boulet L-P ; Cartier A ; Frye B ; Gautrin D ; Germolec DR ; Johnson VJ ; Kashon ML ; Lummus ZL ; Luster MI ; Quirce S ; Rao M ; Sastre J ; Tarlo SM ; Wang W ; Yucesoy, Berran
• Description:
  To investigate the association between single nucleotide polymorphisms (SNPs) located across the major histocompatibility complex and susceptibility to diisocyanate-induced asthma (DA). Methods: The study population consisted of 140 diisocyanate-exposed workers. Genotyping was performed using the Illumina GoldenGate major histocompatibility complex panels. Results: The HLA-E rs1573294 and HLA-DPB1 rs928976 SNPs were associated with an increased risk of DA under dominant (odds ratio [OR], 6.27; 95% confidence interval [CI], 2.37 to 16.6; OR, 2.79, 95% CI, 0.99 to 7.81, respectively) and recessive genetic models (OR, 6.27, 95% CI, 1.63 to 24.13; OR, 10.10, 95% CI, 3.16 to 32.33, respectively). The HLA-B rs1811197, HLA-DOA rs3128935, and HLA-DQA2 rs7773955 SNPs conferred an increased risk of DA in a dominant model (OR, 7.64, 95% CI, 2.25 to 26.00; OR, 19.69, 95% CI, 2.89 to 135.25; OR, 8.43, 95% CI, 3.03 to 23.48, respectively). Conclusion: These results suggest that genetic variations within HLA genes play a role in DA risk. [Description provided by NIOSH]
• Subjects:
  Asthma Asthma, Occupational Genetics Lung Occupational Health Paint Polyurethanes Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety

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• Keywords:
  Bronchial-asthma Exposure-levels Genes Paints Polyurethane-foams Pulmonary-function Pulmonary-system Pulmonary-system-disorders Respiratory-system-disorders Risk-factors Statistical-analysis

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• ISSN:
  1076-2752
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  North Carolina ; Ohio ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  382-387
• Volume:
  56
• Issue:
  4
• NIOSHTIC Number:
  nn:20044139
• Citation:
  J Occup Environ Med 2014 Apr; 56(4):382-387
• Contact Point Address:
  Berran Yucesoy, PhD, Division of Immunology, Allergy and Rheumatology, College of Medicine, University of Cincinnati, Cincinnati, OH 45267-0563; Health Effects Laboratory Division, NIOSH/CDC, Morgantown, WV 26505
• Email:
  yucesobn@ucmail.uc.edu
• CAS Registry Number:
  Diphenylmethane diisocyanate (CAS RN 101-68-8) ; Hexamethylene diisocyanate (CAS RN 822-06-0) ; Toluene diisocyanate (CAS RN 26471-62-5)
• Federal Fiscal Year:
  2014
• NORA Priority Area:
  Healthcare and Social Assistance ; Services
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  True
• Start Date:
  20060901
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• End Date:
  20180831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a3c2862cb4564f4bb6eb196a838c5e2617490d75a43de11b106ff306fcedf98789be56be53b9f4c9036694d908356a7083f21b4cd584f4f801225c8bc5e99bd0
• Download URL:
  https://stacks.cdc.gov/view/cdc/199959/cdc_199959_DS1.pdf
• File Type:
  [PDF - 106.56 KB ]