Panel biomarker study in workers exposed to multiwalled carbon nanotube aerosol

Details

• Personal Author:
  Birch EM ; Fatkhutdinova LM ; Kagan VE ; Khaliullin T ; Kisin EK ; Mustafin I ; Shvedova AA
• Description:
  The aim of the study was to assess potential fibrogenic risk upon real occupational exposure to multi-walled carbon nanotubes (MWCNT) using biomarkers tested in preceding animal experiment. The study was conducted at 2 MWCNT-producing enterprises with the same reactor type. 11 workers who had more than 1 year contact with MWCNT aerosol composed the exposure group, the control group consisted of 14 people. Elemental carbon was evaluated in air samples and the CNT presence was confirmed by TEM-analysis. Blood and induced sputum samples were obtained from workers, TGF-beta1, KL-6 and osteopontin levels evaluated. To assess the relationship between MWCNT exposure and biomarker levels (age, gender, smoking have been chosen as cofounders) generalized linear models including main effects and interactions in-pairs were created. The regression coefficients confidence intervals were refined by bootstrap analysis. TWA respirable MWCNT fraction was up to 6.11 mg/m3. TEM has shown the presence of MWCNT agglomerates sized 0,5-10 mm in all air samples. It was found that exposure to MWCNT aerosol at workplaces may alter the fibrosis biomarkers in blood serum and induced sputum. The levels of TGF-beta1 in serum were dependent on exposure to MWCNTs (beta=10.5, 95%BCa=1.2-51.8), the KL-6 levels in induced sputum were significantly higher in exposure group (beta=235.9, 95%BCa=21.2-482). Osteopontin proved to be as an uninformative indicator. Data suggest that MWCNT exposure may lead to the changes in serum and induced sputum samples specific fibrogenic biomarkers content in workers. MWCNT-producing companies have to introduce control measures, as well as provide the adequate medical services organization. [Description provided by NIOSH]
• Subjects:
  Aerosols Aging Animals Biomarkers Environmental Monitoring Fibrosis Laboratories Lung Lung Diseases Men Occupational Health Pathology Respiratory System Respiratory Tract Diseases Safety Smokers Toxicology Women Workplace

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• Keywords:
  Age-groups Air-samples Cell-damage Cell-function Cellular-function Exposure-levels Humans Laboratory-animals Molecular-biology Molecular-structure Nanotechnology Pulmonary-disorders Pulmonary-function Pulmonary-system Pulmonary-system-disorders Smoking Work-environment Workers

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• ISSN:
  1096-6080
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  Ohio ; OSHA Region 3 ; OSHA Region 5 ; Pennsylvania ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  138
• Issue:
  1
• NIOSHTIC Number:
  nn:20043895
• Citation:
  Toxicologist 2014 Mar; 138(1):160
• Federal Fiscal Year:
  2014
• NORA Priority Area:
  Mining ; Manufacturing ; Public Safety
• Peer Reviewed:
  False
• Source Full Name:
  The Toxicologist. Society of Toxicology 53rd Annual Meeting and ToxExpo, March 23-27, 2014, Phonex, Arizona
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9f0cee7613f016af1d0be6cb9ed36fb3346b02a1b02ac56d2dc532b88b9837f21c2ee9b2011f4834e221901952c0abc73bf0f6094f0b4261d93be8ad2d0d7808
• Download URL:
  https://stacks.cdc.gov/view/cdc/199767/cdc_199767_DS1.pdf
• File Type:
  [PDF - 236.38 KB ]