Carbon nanotubes are toxic in experimental models: what's next, who's being exposed, and should we be concerned

Details

• Personal Author:
  Antonini JM ; Erdely A
• Description:
  Engineered nanomaterials have vast potential with applications in medicine, electronics, and composites. Carbon nanotubes (CNT) represent one such material with broad applications, but this material also has the propensity for significant toxicity. Toxicities include pulmonary and systemic inflammation, fibrosis, immunosuppression, and cardiovascular dysfunction, and evidence is growing that CNT may have properties that influence carcinogenicity. Over the past decade there has been a significant investment in research to examine the in vivo and in vitro toxicity of CNT. Conversely, very little is known about the exposure level and chemical and physical properties of airborne CNT that humans are exposed to, especially in the workplace. These deficiencies make the interpretation of the vast number of experimental studies to human relevance difficult. Initial findings from epidemiological studies of workers handling engineered nanomaterials, recent advancements in detailed facility exposure assessment, pertinent in vivo toxicology studies with dosimetry-based human health implications, regulatory aspects, and risk assessment based on results from animal inhalation studies will be included. The outcome of this session is to provide the most recent human exposure assessment and epidemiological findings and to gather perspective on in vivo toxicology studies involving risk estimates and potential carcinogenicity. This data should have direct influence on the course of newly designed studies and add perspective on previous studies of CNT-induced toxicity. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Carcinogens Cardiovascular Diseases Cardiovascular System Dust Epidemiology Fibrosis Lung Lung Diseases Occupational Health Particulate Matter Respiratory System Respiratory Tract Diseases Safety Toxicology

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• Keywords:
  Airborne-dusts Airborne-particles Cardiovascular-system-disease Cardiovascular-system-disorders Exposure-levels Immune-system In-vitro-study In-vivo-study Nanotechnology Pulmonary-disorders Pulmonary-function Pulmonary-system Pulmonary-system-disorders Respiratory-infections

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• ISSN:
  1096-6080
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  Arizona ; OSHA Region 3 ; OSHA Region 9 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  4
• Volume:
  138
• Issue:
  1
• NIOSHTIC Number:
  nn:20043863
• Citation:
  Toxicologist 2014 Mar; 138(1):4
• Federal Fiscal Year:
  2014
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  False
• Source Full Name:
  The Toxicologist. Society of Toxicology 53rd Annual Meeting and ToxExpo, March 23-27, 2014, Phoenix, Arizona
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:757a4970d6982afd409aa0b784dd0201decd105a87c1d70a190819f4f7c99aa2345c6f70df4dae0b78a684340a7ce1d146105e138f840abd7cb35f628afd4d9f
• Download URL:
  https://stacks.cdc.gov/view/cdc/199738/cdc_199738_DS1.pdf
• File Type:
  [PDF - 238.64 KB ]