Influence of Hyperthyroidism on Rat Lung Cytokine Production and Nuclear Factor (NF)-KappaB Activation Following Ozone Exposure

Details

• Personal Author:
  Brumbaugh K ; Ding M ; Huffman LJ ; Prugh D
• Description:
  Results from previous studies indicate that hyperthyroidism increases the risk of ozone-induced lung toxicity. In the present study, we evaluated cytokine levels in bronchoalveolar lavage fluid from control and hyperthyroid male rats 18 hours after exposure to air or ozone (2 ppm for 3 hours). MIP-2 and MCP-I levels were increased in both control and hyperthyroid rats following ozone. However, the increase in hyperthyroid rats were much greater, MIP-2 (I.S fold) and MCP-I (II fold), when compared to levels in controls. These changes appeared to be relatively specific; bronchoalveolar lavage fluid levels of IL-6, IL-4, and IL-IO were generally low or non-detectable across all groups at this time. We also found that NF-kappa B binding activity was increased at both 4 and 18 hours following ozone exposure in bronchoalveolar lavage cell extracts from hyperthyroid rats relative to controls. Collectively, these results suggest that mechanisms contributing to the enhanced pulmonary inflammatory response to ozone in a hyperthyroid state include an increase in NF-Kappa B activation and an up-regulation of chemokine production. [Description provided by NIOSH]
• Subjects:
  Animals Endocrine System Endocrine System Diseases Environmental Exposure Environmental Monitoring Hazardous Substances Laboratories Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Air-monitoring Animal-studies Endocrine-system-disorders Environmental-exposure Exposure-levels Laboratory-animals Lung-disease Lung-disorders Lung-function Lung-irritants Lung-tissue Pulmonary-function Pulmonary-system Pulmonary-system-disorders Respiratory-system-disorders Toxic-effects

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• ISSN:
  0892-6638
• Document Type:
  Text
• Genre:
  Abstract or Summary ; Proceedings
• Place as Subject:
  Louisiana ; OSHA Region 3 ; OSHA Region 6 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  16
• Issue:
  5
• NIOSHTIC Number:
  nn:20023048
• Citation:
  FASEB J 2002 Mar; 16(5):A961-A962
• CAS Registry Number:
  Ozone (CAS RN 10028-15-6)
• Federal Fiscal Year:
  2002
• Peer Reviewed:
  False
• Source Full Name:
  The FASEB Journal, Experimental Biology 2002, New Orleans, Louisiana, April 20-24, 2002
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a17e068ce52bb70310116fc82faf41170df147e7e65acf0abb85654b46f21ca3ae433ad84faaada84af43e66202a1b8e164b692e6233180c1275dcc99985305e
• Download URL:
  https://stacks.cdc.gov/view/cdc/199633/cdc_199633_DS1.pdf
• File Type:
  [PDF - 243.02 KB ]