Lung Responses to Hypothyroidism, Hyperthyroidism, and Lipopolysaccharide Challenge in Rats

Details

• Personal Author:
  Frazer DG ; Goldsmith WT ; Huffman LJ ; Judy DJ ; Rao KMK
• Description:
  The objectives of this investigation were to study the effects of hypo- and hyperthyroidism on some factors involved in lung injury under basal conditions (air exposure) and during an inflammatory response induced by inhalation exposure to lipopolysaccharide (LPS; 100 microg/ml; 3 h) in adult rats. Thyroid status was altered by thyroidectomy or thyroxine injections for 15 d. Hyperthyroidism alone caused a greater degree of lung cell damage, an increase in the permeability of the alveolar-capillary barrier, a rise in the total number of phagocytic cells obtained by bronchoalveolar lavage (BAL), and enhanced nitric oxide (NO) release by phagocytic cells relative to that in euthyroid control animals. Hypothyroidism alone was associated with opposite effects. Exposure of animals to LPS produced inflammatory responses, which included significant increases in lung cell damage, permeability of the alveolar-capillary barrier, number of phagocytic cells obtained by BAL, and NO production by the phagocytic cells. In general, hyperthyroidism enhanced the effects of LPS, while hypothyroidism reduced LPS-induced responses. These results suggest that thyroid status alone can affect some of the factors involved in lung injury and also modulate some of the inflammatory effects of LPS. Hyperthyroidism tends to enhance lung injury, while hypothyroidism seems to reduce lung injury. [Description provided by NIOSH]
• Subjects:
  Animals Endocrine System Environmental Exposure Laboratories Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Animal Studies Endocrine System Disorders Endocrinology Exposure Levels Inhalation Studies Laboratory Animals Lung Disorders Phagocytes Phagocytic Activity Pulmonary System Disorders Respiratory System Disorders Thyroid Gland Disorders

  More +
• ISSN:
  1528-7394
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  61
• Issue:
  7
• NIOSHTIC Number:
  nn:20020705
• Citation:
  J Toxicol Environ Health A 2000 Dec; 61(7):623-639
• Contact Point Address:
  Linda Huffman, PhD, M/S 2015, NIOSH, 1095 Willowdale Road, Morgantown, WV 26505, USA
• Email:
  ljh3@cdc.gov
• CAS Registry Number:
  Nitric oxide (CAS RN 10102-43-9)
• Federal Fiscal Year:
  2001
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Toxicology and Environmental Health, Part A: Current Issues
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ed16ed8631d299a850f8cb05db648b4b7e0ff07fadf49a94bc4855c4a70ae8229446021befe5b70195ee4ad63ded02b083cf30461404924b39ffdcf4e6b24833
• Download URL:
  https://stacks.cdc.gov/view/cdc/198383/cdc_198383_DS1.pdf
• File Type:
  [PDF - 380.12 KB ]