Age Differentially Influences Estrogen Receptor-Alpha (ERalpha) and Estrogen Receptor-Beta (ERbeta) Gene Expression in Specific Regions of the Rat Brain

Details

• Personal Author:
  Kashon ML ; Merchenthaler I ; Rosewell KL ; Shughrue PJ ; Wilson ME ; Wise PM
• Description:
  Estradiol's ability to influence neurochemical events that are critical to female reproductive cyclicity and behavior decreases with age. We tested the hypothesis that decreases in estrogen receptor-alpha (ERalpha) and/or ERbeta mRNA explain the brain's declining responsiveness to estradiol. We assessed ERalpha and ERbeta mRNA levels in intact and ovariectomized estradiol-treated rats. ERbeta mRNA was detected in several brain regions and decreased by middle-age in the cerebral cortex and supraoptic nucleus of estradiol-treated rats. ERbeta mRNA levels exhibited a diurnal rhythm in the suprachiasmatic nucleus of young and middle-aged rats and this rhythm was blunted in old rats. We examined ERalpha mRNA in the periventricular preoptic, medial preoptic, ventromedial and arcuate nuclei, and it was decreased only in the periventricular preoptic nucleus of the old rats. In summary, the expression of ERalpha and ERbeta mRNAs is differentially modulated in the aging brain and changes are region specific. [Description provided by NIOSH]
• Subjects:
  Age Factors Aging Animals Estrogens Nervous System Occupational Health Safety Urogenital System
• Keywords:
  Age-factors Age-groups Animal-studies Author Keywords: Estradiol Brain-function ER Estrogenic-hormones Female Fertility Reproduction Reproductive-effects Reproductive-system

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• ISSN:
  0047-6374
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  123
• Issue:
  6
• NIOSHTIC Number:
  nn:20022956
• Citation:
  Mech Ageing Dev 2002 Mar; 123(6):593-601
• Contact Point Address:
  Departmen of Physiology, College of Medicine, University of Kentucky, 800 Rose Street, Lexington, KY 40536, USA
• Federal Fiscal Year:
  2002
• Peer Reviewed:
  True
• Source Full Name:
  Mechanisms of Ageing and Development
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4b042e132c94a15bf62d8d9801da47bf4062b2a803706ceba6d1b3e5e610e967dc808570ed481caa41cdaa9779739e6a139700390de96d57362a64e747f8e787
• Download URL:
  https://stacks.cdc.gov/view/cdc/199560/cdc_199560_DS1.pdf
• File Type:
  [PDF - 142.00 KB ]