Aging, Estradiol and Time of Day Differentially Affect Serotonin Transporter Binding in the Central Nervous System of Female Rats

Details

• Personal Author:
  Duncan MJ ; Krajnaka K ; Rosewell KL ; Wise PM
• Description:
  Estrogen-related changes in serotonergic neuronal transmission, including changes in the number of serotonin transporter (SERT) binding sites, have been cited as a possible cause for changes in mood, memory and sleep that occur during the menopausal transition. However, both aging and estradiol regulate SERT binding sites in the brain. The goal of this experiment was to determine how aging and estrogen interact to regulate SERT levels in the forebrain of young and reproductively senescent female Sprague-Dawley rats using [3H]paroxetine. The density of specific [3H]paroxetine binding in various brain regions was compared in young (2-4 months) and reproductively senescent (10-12 months) female rats at three times of day. In most brain regions examined, estrogen and aging independently increased the number of [3H]paroxetine binding sites. The only region that displayed a reduction in [3H]paroxetine binding with age was the suprachiasmatic nucleus (SCN). Time of day influenced [3H]paroxetine binding in the SCN and the paraventricular thalamus (PVT), two regions known to be involved in the regulation of circadian rhythms. Aging and/or estrogen also altered the pattern of binding in these regions. Thus, based on the results of this study, we conclude that aging and estrogen both act to regulate SERT binding sites in the forebrain of female rats, and that this regulation is region specific. [Description provided by NIOSH]
• Subjects:
  Age Factors Animals Circadian Rhythm Estrogens Laboratories Nervous System Occupational Health Safety Steroids Urogenital System
• Keywords:
  Age-factors Animal-studies Brain-function Central-nervous-system Circadian-rhythms Estrogenic-hormones Laboratory-animals Neurotransmitters Reproductive-effects
• ISSN:
  0006-8993
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  California ; Kentucky ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 9 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  87-94
• Volume:
  990
• Issue:
  1
• NIOSHTIC Number:
  nn:20032138
• Citation:
  Brain Res 2003 Nov; 990(1-2):87-94
• Contact Point Address:
  National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Engineering and Control Technology Branch, MS2027, 1095 Willowdale Road, Morgantown, WV 26505
• Email:
  mqk1@cdc.gov
• CAS Registry Number:
  (-)-Paroxetine (CAS RN 61869-08-7)
• Federal Fiscal Year:
  2004
• Peer Reviewed:
  True
• Source Full Name:
  Brain Research
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b5fc0496286b8c1cbf4039915a13262b9e97b6f35ab5427355b40fd8644effcbdfbb8263881181b11b7df4ab17a9e76e8a86ea790ab3e9b43b77b7f551fc1150
• Download URL:
  https://stacks.cdc.gov/view/cdc/186186/cdc_186186_DS1.pdf
• File Type:
  [PDF - 276.04 KB ]