Predictors of Chronic Beryllium Disease and Sensitization

Details

• Personal Author:
  Aronchick J ; Bush A ; Hertzberg V ; Parker J ; Regovich J ; Reily MJ ; Rice C ; Rosenman, Kenneth D. ; Rossman MD
• Description:
  A cohort of 1,464 current and former workers from two beryllium processing facilities in Eastern Pennsylvania were screened utilizing chest radiographs interpreted by a panel of three "B" readers, spirometry and blood beryllium lymphocyte proliferation testing (BLPT) to look at predictors of Chronic Beryllium Disease (CBD) and Beryllium Sensitization (BS). Individuals with radiographs which at least 2 of 3 "B" readers interpreted as showing changes consistent with pneumoconiosis and/or two positive BLPTs were referred for bronchoscopy with bronchial lavage and biopsy. Sixty (4.1%) individuals were diagnosed with definite or probable CBD, another 16 (1.1%) with possible CBD, 72 (4.9%) with BS and 10 (0.7%) with possible BS. Predictors examined included: facility A vs. facility B the OR = 1.5 (95% CI .9-2.7)for CBD and the OR = 1.3 (95% CI .8-2.2) for BS; female vs. male gender the OR = .9 (95% CI .4- 2.8) for CBD and the OR = 2.3 (95% CI 1.1-4.9) for BS; never vs. ever smoked the OR = 1.3 (95% CI .8-2.4) for CBD and the OR = 1.5 (95% CI .9-2.5) for BS. No association was found between CBD and duration (p = 0.3). BS increased with shorter duration
• Subjects:
  Beryllium Genetics Hematologic Tests Occupational Health Radiography Respiratory Function Tests Respiratory Tract Diseases Safety
• Keywords:
  Beryllium-compounds Beryllium-disease Beryllium-poisoning Blood-analysis Blood-sampling Chest-X-rays Genes Genetic-factors Pneumoconiosis Pulmonary-system-disorders Respiratory-system-disorders Spirometry

  More +
• ISSN:
  1073-449X
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Abstract or Summary
• Place as Subject:
  Georgia ; Michigan ; Ohio ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; Pennsylvania ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  165
• Issue:
  8
• NIOSHTIC Number:
  nn:20022925
• Citation:
  Am J Respir Crit Care Med 2002 Apr; 165(8)(Suppl):A48
• Federal Fiscal Year:
  2002
• NORA Priority Area:
  Research Tools and Approaches: Exposure Assessment Methods
• Performing Organization:
  Michigan State University
• Peer Reviewed:
  False
• Start Date:
  19950930
• Source Full Name:
  American Journal of Respiratory and Critical Care Medicine, 2002 International Conference, The American Thoracic Society, Atlanta Georgia, May 17-22, 2002
• Supplement:
  Suppl
• End Date:
  20010929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:15681d4cf3d46d98d27340ccf3860628b689609fbaa3fb2c6aeda2999b952184e429c0ced6269eed0347096ef36c991f4d129d6c3dca1607289ca062eb677b58
• Download URL:
  https://stacks.cdc.gov/view/cdc/199537/cdc_199537_DS1.pdf
• File Type:
  [PDF - 259.95 KB ]