Waf-1 (p21) and p53 Polymorphisms in Breast Cancer

Details

• Personal Author:
  Frye BL ; Keshava C ; McCanlies EC ; Weston A ; Wolff MS
• Description:
  p53 is a transcription factor for Waf-1/p21, a cyclin-dependent kinase inhibitor. Certain polymorphic variants of Waf-1 and p53 have been evaluated for their association with cancer risk. Previous studies indicated that certain p53 polymorphisms confer an increased risk of breast cancer [odds ratios (ORs) and 95% confidence intervals (CIs) = 2.9, 1.4-6.3 Carcinogenesis (Lond.), 17: 1313, 1996; 2.5, 1.3-4.8 Cancer Epidemiol. Biomark. Prev., 6: 105, 1997; and 1.5, 1.1-2.0, Anticancer Res., 18: 2095, 1998). The primary objectives of this study were to test the hypotheses that the serine variant (codon 31 polymorphism) of Waf-1 is also involved in this process and that there is an interaction between Waf-1 and p53 polymorphisms. To do this, Waf-1 and p53 genotypes were determined for women enrolled in a breast cancer case-control study (Caucasians, African-Americans and Latinas; 487 Waf-1 and 504 p53 genotypes were obtained). Multivariate logistic regression was used to evaluate possible associations between Waf-1 and p53 polymorphisms, race, and menopause. The primary aim was to determine whether an interaction between Waf-1 and p53(1-2-1) existed. Whereas multivariate analysis suggested associations between breast cancer and inheritance of Waf-1ser31 in African-Americans (OR, 2.32; 95% CI = 0.66-5.60; n = 37 cases and 65 controls) and Latinas (OR, 2.22; 95% CI = 0.71-6.89; n = 30 cases and 75 controls), and inheritance of p53(1-2-1) in Caucasians (OR, 3.15; 95% CI = 1.14-8.89; n = 93 cases and 187 controls), we did not see an interaction between Waf-1(ser31) and p53(1-2-1). Consistent with the finding that p531(1-2-1) is a risk factor for Caucasian women was the observation of a strong interaction between race and p53 (P < 0.01). [Description provided by NIOSH]
• Subjects:
  Carcinogens Genetics Neoplasms Occupational Health Race Factors Safety Women
• Keywords:
  Breast-cancer Cancer Carcinogenesis Genetic-factors Humans Racial-factors Sensitivity-testing
• ISSN:
  1055-9965
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  127-130
• Volume:
  11
• Issue:
  1
• NIOSHTIC Number:
  nn:20022906
• Citation:
  Cancer Epidemiol Biomark Prev 2002 Jan; 11(1):127-130
• Contact Point Address:
  National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, MS-L3014, 1095 Willowdale Road, Morgantown, WV 26505-2888
• Email:
  agw8@cdc.gov
• Federal Fiscal Year:
  2002
• NORA Priority Area:
  Research Tools and Approaches: Cancer Research Methods
• Peer Reviewed:
  True
• Source Full Name:
  Cancer Epidemiology, Biomarkers & Prevention
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:31259339c80a66d5778d61916b7565ec27ee9adf87d8217f21ee86a341f6050fb0a117c375a0723628c93f570d138706a0519f107803ccc73a28c6a61f17fcfe
• Download URL:
  https://stacks.cdc.gov/view/cdc/199523/cdc_199523_DS1.pdf
• File Type:
  [PDF - 173.18 KB ]