Cytokine Polymorphisms in Chronic Inflammatory Diseases with Reference to Occupational Diseases

Details

• Personal Author:
  Kashon ML ; Luster MI ; Yucesoy, Berran
• Description:
  Genes which encode inflammatory cytokines are subject to polymorphisms in their regulatory regions that may effect both the level and ratio of cytokines produced in response to exogenous stimuli. These variant alleles are observed in a large percent of the population and are often associated with increased or decreased susceptibility or severity (modifiers) to infectious, immune or inflammatory diseases. Environmental factors can also play either a direct (i.e., causative factor) or indirect (modifying factor) role in these diseases. Thus, it would follow that gene-environment interactions would effect the expression and/or progression of the disease. In the present review, the concept that some of the common allelic variants found in cytokine genes represent modifying factors in chronic inflammatory diseases associated with occupational exposure is discussed. [Description provided by NIOSH]
• Subjects:
  Beryllium Chronic Disease Communicable Diseases Dermatitis Environmental Health Genetics Occupational Exposure Occupational Health Respiratory Tract Diseases Safety
• Keywords:
  Author Keywords: Single Nucleotide Polymorphisms Beryllium-disease Chronic-inflammation Chronic Inflammatory Diseases Cytokine Network Diseases Environmental-factors Genes Genetic-factors Hepatitis Infectious-diseases Occupational-exposure Occupational-health Pulmonary-system-disorders

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• ISSN:
  1566-5240
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  39-48
• Volume:
  3
• Issue:
  1
• NIOSHTIC Number:
  nn:20022658
• Citation:
  Curr Mol Med 2003 Feb; 3(1):39-48
• Contact Point Address:
  Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
• Email:
  BYucesoy@cdc.gov
• Federal Fiscal Year:
  2003
• Peer Reviewed:
  True
• Source Full Name:
  Current Molecular Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a50f7c261f73d4ea514a95df1b29bfedb0b45247ca6f1634751cdd1499693b4d98bb99cb957ee8fad7701e4bf7595ba402b302d46e1fb3f8b2fe6ea28d717ed9
• Download URL:
  https://stacks.cdc.gov/view/cdc/199356/cdc_199356_DS1.pdf
• File Type:
  [PDF - 92.02 KB ]