Otoneurotoxic Effects of Solvents: Review of the Literature

Details

• Personal Author:
  Chouaniere D ; Demange V ; Johnson AC ; Loquet G ; Morata, Thais C. ; Perrin P
• Description:
  Organic solvents are used in the industrial environment, and the combined exposure to noise and solvents (pure or in mixtures) is of concern to numerous workers from various economic sectors. Although the effects of organic solvents on the central nervous system are well known, their sensorineural effects, particularly in the auditory system, constitute a new area for research. Studies conducted with experimental animals have shown that the combined exposure to solvents and noise results in a synergistic effect on the auditory system, and that the lesions can be both cochlear and retrocochlear. In humans, there is now evidence from epidemiological studies in the occupational environment suggesting an ototoxic effect of some single solvents and solvent mixtures, as well as evidence of an interaction between noise and solvents on the auditory function. Published in French. [Description provided by NIOSH]
• Subjects:
  Nervous System Noise Occupational Health Safety Solvents Styrene Toluene Xylenes
• Keywords:
  Neurotoxic-effects Neurotoxicity Organic-solvents Ototoxicity Styrenes Toluenes
• ISSN:
  1014-8221
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  141-150
• Volume:
  11
• Issue:
  3
• NIOSHTIC Number:
  nn:20022611
• Citation:
  Otorhinolaryngol Nova 2001 Jan; 11(3-4):141-150
• Contact Point Address:
  D. Chouaniere, Department d'Epidemiologie en Entreprises, INRS, Avenue de Bourgogne, BP 27, F-54 501 Vandoeuvre-les-Nancy (France)
• Email:
  chouaniere@inrs.fr
• CAS Registry Number:
  Styrene (CAS RN 100-42-5) ; Toluene (CAS RN 108-88-3) ; Trichloroethylene (CAS RN 79-01-6) ; Xylene (CAS RN 1330-20-7)
• Federal Fiscal Year:
  2001
• NORA Priority Area:
  Neurotoxic Disorders ; Neurotoxic Effects
• Peer Reviewed:
  True
• Source Full Name:
  Oto-Rhino-Laryngologia Nova
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2456560260cfc58f3018fe47b3f875b9439059f25a7138ffbeb517021d8f23ad4cf6c3c5177372c0bc7842cc3bd9fd88e2609d97488c30a26606b9a6b3bf135a
• Download URL:
  https://stacks.cdc.gov/view/cdc/199328/cdc_199328_DS1.pdf
• File Type:
  [PDF - 89.14 KB ]