Auditory Function After Single or Combined Exposure to Styrene: A Review

Details

• Personal Author:
  Campo P ; Morata, Thais C.
• Description:
  Styrene is a widely used organic solvent, heavily employed in many manufacturing industries, as well as in other economic sectors. Recently, evidence is beginning to accumulate on the deleterious effects that styrene exposures have on the auditory system. In rats, a well-suited metabolic animal model for these studies, aromatic solvents such as styrene have been shown to affect the auditory sensitivity mainly in the mid-frequency range. Outer hair cells are the primary targets within the organ of Corti, although the spiral ganglions are not spared. Therefore, styrene must be considered as an ototoxic chemical agent that can be potentially neurotoxic. Finally, noise-styrene exposures can have synergistic effects on the auditory system. The findings reported in both human and animal studies indicate that exposures to styrene, or to styrene associated to noise, may dramatically impact occupational hearing conservation practices and legislation. Both human and animal studies will be summarized in discussing the effects of styrene alone or in combination with noise. Gaps in scientific knowledge are highlighted to assist in future research. [Description provided by NIOSH]
• Subjects:
  Environmental Exposure Hearing Hearing Loss Hearing Loss, Noise-Induced Nervous System Noise Occupational Health Safety Solvents Styrene
• Keywords:
  Auditory System Exposure Levels Hearing Impairment Hearing Level Hearing Loss Neurotoxic Effects Neurotoxicity Organic Solvents Styrenes Synergism
• ISBN:
  1901747018
• Publisher:
  NRN Publications
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  293-304
• NIOSHTIC Number:
  nn:20021396
• Citation:
  Noise induced hearing loss: basic mechanisms, prevention and control. Henderson D, Prasher D, Kopke R, Salvi R, Hamernik R, eds. London: NRN Publications, 2001 Jan; :293-304
• Email:
  tmorata@cdc.gov
• CAS Registry Number:
  Styrene (CAS RN 100-42-5)
• Editor(s):
  Henderson D; Prasher D; Kopke R; Salvi R; Hamernik R
• Federal Fiscal Year:
  2001
• Peer Reviewed:
  False
• Source Full Name:
  Noise induced hearing loss: basic mechanisms, prevention and control
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a7672e5d0591fc9ce5eecc80d4c9182f6ecdd599c11a1c8be94e6313741bec07ce7e774ee21612f4e02b13595cc62bf0fe18e1ce5e41866eda5f3e51542335e4
• Download URL:
  https://stacks.cdc.gov/view/cdc/198731/cdc_198731_DS1.pdf
• File Type:
  [PDF - 733.98 KB ]