Silica-Induced Toxicity: In Vitro and In Vivo Protective Effects of Taurine

Details

• Personal Author:
  Pack D ; Patel S ; Vallyathan V
• Description:
  Taurine has been suggested to have cytoprotective actions through different mechanisms including antioxidant effects. Taurine has been proposed to be a membrane stabilizer thereby preventing oxidative damage. The aim of the present studies was to test whether taurine might act to attenuate silica-induced toxicity in vitro and in vivo. The presence of taurine resulted in a reduction of cytotoxicity with alveolar macrophages exposed to crystalline silica. To investigate further whether taurine would function effectively in the prevention of in vivo toxicity from exposure to silica we exposed rats by intratracheal instillation to a single dose of 5 mg silica coated with 100 mM taurine and compared the pulmonary response to rats exposed to silica or vehicle saline. Rats were sacrificed 1, 3, or 7 days postexposure, and lungs were lavaged to monitor inflammatory cells (alveolar macrophages, neutrophils, lymphocytes, eosinophils), leakage of albumin, protein and enzymes (LDH, NAG), and chemiluminescence as markers of inflammation, cytotoxicity and reactive oxygen species generated, respectively. Surface coating and coexposure of silica with taurine significantly decreased silica-induced lung injury. In conclusion, taurine showed beneficial effects in both in vitro and in vivo models of silica toxicity. This result confirms previous studies obtained in other models of lung injury. [Description provided by NIOSH]
• Subjects:
  Cytotoxins Laboratories Lung Diseases Occupational Health Respiratory Tract Diseases Safety
• Keywords:
  Cytotoxic-effects In-vitro-studies In-vivo-studies Laboratory-animals Lung-disease Pulmonary-system-disorders Respiratory-system-disorders
• ISSN:
  1096-6080
• Publisher:
  Society of Toxicology
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  45-46
• Volume:
  72
• NIOSHTIC Number:
  nn:20022541
• Citation:
  Toxicologist 2003 Mar; 72(S-1):45-46
• CAS Registry Number:
  Quartz (SiO2) (CAS RN 14808-60-7) ; Taurine (CAS RN 107-35-7)
• Federal Fiscal Year:
  2003
• NORA Priority Area:
  Work Environment and Workforce: Mixed Exposures
• Peer Reviewed:
  False
• Source Full Name:
  The Toxicologist. Society of Toxicology 42nd Annual Meeting and ToxExpo, Cutting-Edge Science, Networking, New Perspectives, March 9-13, 2003, Salt Lake City, Utah
• Supplement:
  S-1
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:561dab41f727d1eb03df21366e604d3d0f48a9c22c6736ebc1dffe4dda13758fef170d39c0cb545c643a31abe6d419d5a2364f7079b6db1e714d33469b73bf75
• Download URL:
  https://stacks.cdc.gov/view/cdc/199285/cdc_199285_DS1.pdf
• File Type:
  [PDF - 67.79 KB ]