Comparative Toxicity of Nanomaterials In Vitro and In Vivo

Details

• Personal Author:
  Arepalli S ; Baron, Paul A. ; Castranova, Vincent ; Gorelik O ; Hubbs A ; Johnson VJ ; Kagan VE ; Kisin E ; Maynard AD ; Mercer RR ; Murray AR ; Potapovich AI ; Shvedova AA
• Description:
  Society is currently amidst with revolutionary developments of remarkable new technologies based on novel applications of nanomaterials. A comparative in vitro study of nanosized particles revealed dose-dependent formation of granulomatous bronochointerstitial pneumonia, fibrosis, and changed pulmonary function in C57BL/6 mice. Administration of CNT to mice also resulted in a dose-dependent augmentation of biomarkers of inflammation quantified by lavage cell counts, total protein, lactate dehydrogenase and glutamyltranspeptidase activities in BAL fluids and accumulation of pro-inflammatory and pro-fibrotic cytokines. Overall, our data suggest that in vivo exposure to CNT leads to pulmonary toxicity realized through the synergized interactions of inflammatory response and oxidative stress culminating in the development of multifocal granulomatous pneumonia and fibrosis. The value of both approaches will be discussed in line with assessment of adverse outcomes of nanomaterials. [Description provided by NIOSH]
• Subjects:
  Animals Biomarkers Cytotoxins Environmental Monitoring Fibrosis Laboratories Occupational Health Respiratory Tract Diseases Safety
• Keywords:
  Animal-studies Cytotoxic-effects Cytotoxicity Exposure-assessment Exposure-levels In-vitro-studies In-vivo-studies Laboratory-animals Nanotechnology Pulmonary-system-disorders Respiratory-system-disorders

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• ISSN:
  0065-7727
• Document Type:
  Text
• Genre:
  Abstract or Summary ; Proceedings
• Place as Subject:
  Ohio ; OSHA Region 3 ; OSHA Region 5 ; OSHA Region 6 ; Pennsylvania ; Texas ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; OD - Office of the Director ; DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  229
• NIOSHTIC Number:
  nn:20027576
• Citation:
  Abstr Pap - Am Chem Soc 2005 Mar; 229(Pt 1):014-IEC
• Federal Fiscal Year:
  2005
• NORA Priority Area:
  Disease and Injury: Asthma and Chronic Obstructive Pulmonary Disease
• Peer Reviewed:
  False
• Part Number:
  1
• Source Full Name:
  Abstracts of papers - American Chemical Society
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0f7d39e3a925ba8adf73377afcabe9a03f38cc851a8bde5628a9b771f65d8c7b42c3a491ff88ee63161cdba06fb35e0bf210ee2fd36763fd9df63d8ce6ccc52c
• Download URL:
  https://stacks.cdc.gov/view/cdc/197600/cdc_197600_DS1.pdf
• File Type:
  [PDF - 381.61 KB ]