A Sampling and Analysis Method for Two Amino Alcohols

Details

• Personal Author:
  Grote, Ardith A.
• Description:
  During a recent NIOSH field survey, thermal desorption tubes were used to qualitatively determine any volatile organic compounds to which the workers were being exposed. Two major compounds in the samples were identified by gas chromatography-mass spectrometry as N,N-dimethylethanolamine (DMEA) and N,N-dimethylisopropanolamine (DMIPA). A short-term method development was con- ducted to quantify full-shift concentrations of these compounds, potentially at fairly high levels. A desorption study was conducted using various solid sorbents-silica gel, carbon molecular sieve, and XAD resins. Methanol was used as the desorbing solvent. Only the XAD resins gave desorption efficiencies above the NIOSH criteria of 75% at various levels. Further study showed only the XAD- 7 sorbent efficiently trapped these particular amines. The gas chromatography-flame ionization (GC- FID) method used a dimethylpolysiloxane bonded phase capillary column. The limits of detection (LOD) and quantitation (LOQ) for both amines were approximately 4 ug and 10 ug per sample respectively. Calibration curves were linear over a range of 4 ug to 550 ug per sample. Additional studies were conducted to check the storage stability of spiked samples, showing that samples were stable for at least three weeks when stored cold (- 4 C). The method was successfully used in a field study for the analysis of over 200 personal samples. The method will be published in the next supplement of the NIOSH Manual of Analytical Methods (NMAM). [Description provided by NIOSH]
• Subjects:
  Amino Acids Mass Spectrometry Occupational Health Safety
• Keywords:
  Amino-compounds Analytical-methods Exposure-levels Gas-chromatography Mass-spectrometry Organic-compounds Sampling-methods Workers
• Publisher:
  American Industrial Hygiene Association
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  California ; Ohio ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  86
• NIOSHTIC Number:
  nn:20022499
• Citation:
  American Industrial Hygiene Conference and Exposition, June 1-6, 2002, San Diego, California. Fairfax, VA: American Industrial Hygiene Association, 2002 Jun; :86
• CAS Registry Number:
  N,N-Dimethylaniline (CAS RN 121-69-7) ; Poly(dimethylsiloxane) (CAS RN 9016-00-6)
• Federal Fiscal Year:
  2002
• Peer Reviewed:
  False
• Source Full Name:
  American Industrial Hygiene Conference and Exposition, June 1-6, 2002, San Diego, California
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9f9e2d4354a9f78632986ada2617b392e7a095edb3c08734ff78c700f793b97e964b63bf469cd18f4f0bd6e572676451401cda696b6777538203372352277357
• Download URL:
  https://stacks.cdc.gov/view/cdc/199254/cdc_199254_DS1.pdf
• File Type:
  [PDF - 486.60 KB ]