Improving Risk Assessment: Research Opportunities in Dose Response Modeling to Improve Risk Assessment

Details

• Personal Author:
  Andersen M ; Bailer AJ ; Bayard S ; Chen C ; Clewell H ; Conolly R ; Crump K ; Dunson D ; Finkel A ; Haber L ; Hattis D ; Jarabek AM ; Kodell R ; Krewski D ; Thomas D ; Thorslund T ; Wassell, James T. ; Zeise L
• Description:
  Substantial improvements in dose response modeling for risk assessment may result from recent and continuing advances in biological research, biochemical techniques, biostatistical/mathematical methods and computational power. This report provides a ranked set of recommendations for proposed research to advance the state of the art in dose response modeling. The report is the result of a meeting of invited workgroup participants charged with identifying five areas of research in dose response modeling that could be incorporated in a national agenda to improve risk assessment methods. Leading topics of emphasis are interindividual variability, injury risk assessment modeling, and procedures to incorporate distributional methods and mechanistic considerations into now-standard methods of deriving a reference dose (RfD), reference concentration (RfC), minimum risk level (MRL) or similar dose-response parameter estimates. [Description provided by NIOSH]
• Subjects:
  Epidemiology Occupational Health Risk Assessment Safety
• Keywords:
  Author Keywords: Interindividual Variability Bayesian Analysis Dose-response Injury Risk Latent Variables Markov Chain Monte Carlo Analysis Mathematical-models Risk-analysis Statistical-analysis
• ISSN:
  1080-7039
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  California ; Colorado ; District of Columbia ; Louisiana ; Massachusetts ; North Carolina ; Ohio ; OSHA Region 1 ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 6 ; OSHA Region 8 ; OSHA Region 9 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSR - Division of Safety Research ; EID - Education and Information Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  8
• Issue:
  6
• NIOSHTIC Number:
  nn:20022470
• Citation:
  Hum Ecol Risk Assess 2002 Oct; 8(6):1421-1444
• Editor(s):
  Stayner L; Toraason M; Hattis D
• Federal Fiscal Year:
  2003
• NORA Priority Area:
  Research Tools and Approaches: Risk Assessment Methods
• Peer Reviewed:
  True
• Source Full Name:
  Human and Ecological Risk Assessment
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d25e3b5e0e6b5d70bfb58f6118eab18aa7f1d48415ad24504700e548e58659dd72bc0418fbde86b5eefae2ce03420aa73357b23f59a87b034a4325afb5581c23
• Download URL:
  https://stacks.cdc.gov/view/cdc/199239/cdc_199239_DS1.pdf
• File Type:
  [PDF - 350.67 KB ]