Diseases Caused by Silica: Mechanisms of Injury and Disease Development

Details

• Personal Author:
  Chen F ; Ding M ; Mossman B ; Shi X ; Vallyathan V ; Yucesoy, Berran
• Description:
  While silica particles are considered to be fibrogenic and carcinogenic agents, the mechanisms responsible are not well understood. This article summarizes literature on silica-induced accelerated silicosis, chronic silicosis, silico-tuberculosis, bronchogenic carcinoma, and immune-mediated diseases. This article also discusses the generation of reactive oxygen species (ROS) that occurs directly from the interaction of silica with aqueous medium and from silica-stimulated cells, the molecular mechanisms of silica-induced lung injuries with focus on silica-induced NF-kappaB activation, including its mechanisms, possible attenuation and relationship to silica-induced generation of cyclooxygenase II and TNF-alpha. Silica-induced AP-1 activation, protooncogene expression, and the role of ROS in these processes are also briefly discussed. [Description provided by NIOSH]
• Subjects:
  Carcinogens Free Radicals Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety Silicon Dioxide
• Keywords:
  Author Keywords: Silica Bronchial-cancer Carcinogenesis Cell-alteration Fibrogenesis Free-radical-generation Free-radicals Immune-system-disorders Lung-cells Lung-disease NF-kB Oncogenic-agents Oxygen-uptake Pharmacodynamics Physiopathology Pulmonary-system-disorders Reactive Oxygen Species Respiratory-system-disorders Silica-dusts Silicosis

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• ISSN:
  1567-5769
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  173-182
• Volume:
  2
• Issue:
  2
• NIOSHTIC Number:
  nn:20022203
• Citation:
  Int Immunopharmacol 2002 Feb; 2(2-3):173-182
• Contact Point Address:
  Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
• Email:
  vav1@cdc.gov
• Federal Fiscal Year:
  2002
• Peer Reviewed:
  True
• Source Full Name:
  International Immunopharmacology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f577307f9d9918e4dcb615708eb2fcf7b706c8f25f68484eb27838b4d24904af03d4343c722dceb256fb25c4d122a5dec101260948d1e5f592bf8c26c575f71c
• Download URL:
  https://stacks.cdc.gov/view/cdc/199065/cdc_199065_DS1.pdf
• File Type:
  [PDF - 130.00 KB ]