Molecular Mechanisms of Cr(VI)-Induced Carcinogenesis

Details

• Personal Author:
  Ding M ; Shi X
• Description:
  Although Cr(VI)-containing compounds are well documented carcinogens, their mechanism of action is still not well understood. Recent studies have suggested that reduction of Cr(VI) to its lower oxidation states and related free radical reactions play an important role in Cr(VI)-induced carcinogenesis. This article summarizes recent studies from our laboratory on (a) the reduction of Cr(VI) by ascorbate, diol- and thiol-containing molecules, certain flavoenzymes, cell organelles, intact cells, and whole animals; (b) free radical production in both non-cellular and cellular systems; and (c) Cr(VI)-induced DNA damage, activation of nuclear transcription factor KB (NF-kappaB), activator protein-1, p53, hypoxia-inducible factor-1, vascular endothelial growth factor, tyrosine phosphorylation, apoptosis, cell growth arrest, and gene expression profile. [Description provided by NIOSH]
• Subjects:
  Antioxidants Carcinogens Chromium DNA Enzymes Free Radicals Genetics Laboratories Neoplasms Occupational Health Safety

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• Keywords:
  Apoptosis Author Keywords: Cr(VI) Cancer Carcinogenesis Cell-alteration Cell-biology Cell-growth Cell Growth Arrest Chromium-compounds DNA-damage Enzymatic-effects Enzyme-activity Free-radicals Genes Laboratory-testing Molecular-biology Molecular-structure Oxidation-reduction-reactions Oxidative-enzymes Reactive Oxygen Species Signal Transduction Transcriptional Regulation

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• ISSN:
  0300-8177
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  293-300
• Volume:
  234
• Issue:
  1
• NIOSHTIC Number:
  nn:20022164
• Citation:
  Mol Cell Biochem 2002 May-Jun; 234-235(1-2):293-300
• Contact Point Address:
  Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
• Email:
  xshi@cdc.gov
• Federal Fiscal Year:
  2002
• NORA Priority Area:
  Research Tools and Approaches: Cancer Research Methods
• Peer Reviewed:
  True
• Source Full Name:
  Molecular and Cellular Biochemistry
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6f7f38b98b50c2b06addae4b67bf0a34e81bbb36f3adc65213abe5baee8baf53cb41dce1f841e3bdb696a915d670eac6f9ea9108c89cd26930ef021ca03b61e3
• Download URL:
  https://stacks.cdc.gov/view/cdc/199049/cdc_199049_DS1.pdf
• File Type:
  [PDF - 70.22 KB ]