Update of the Follow-Up of Mortality and Cancer Incidence Among European Workers Employed in the Vinyl Chloride Industry

Details

• Personal Author:
  Andersen A ; Boffetta P ; Colin D ; Comba, Paul ; De Santis M ; Deddens J ; Engholm G ; Hagmar L ; Langard S ; Lundberg I ; McElvenny D ; Pirastu R ; Sali D ; Simonato L ; Ward E
• Description:
  Although vinyl chloride is an established cause of liver angiosarcoma, the evidence is inconclusive on whether it also causes other neoplastic and nonneoplastic chronic liver diseases as well as neoplasms in other organs. Furthermore, the shape of the dose-response relation for angiosarcoma is uncertain. We have extended for approximately 8 years the mortality and cancer incidence follow-up of 12,700 male workers in the vinyl chloride industry in four European countries. All-cause mortality was lower than expected, whereas cancer mortality was close to expected. A total of 53 deaths from primary liver cancer (standardized mortality ratio 2.40, 95% confidence interval = 1.80 - 3.14) and 18 incident cases of liver cancer were identified, including 37 angiosarcomas, 10 hepatocellular carcinomas, and 24 liver cancers of other and unknown histology. In Poisson regression analyses we observed a marked exposure response for all liver cancers, angiosarcoma, and hepatocellular carcinoma. The exposure-response trend estimated for liver cancer in analyses restricted to cohort members with cumulative exposures of <1,500 parts per million-years was close to that estimated for the full cohort (relative risk of 2.0 per logarithmic unit of cumulative dose). No strong relation was observed between cumulative vinyl chloride exposure and other cancers. Although cirrhosis mortality was decreased overall, there was a trend with cumulative exposure. [Description provided by NIOSH]
• Subjects:
  Digestive System Digestive System Diseases Epidemiology Liver Mortality Neoplasms Occupational Health Safety Vinyl Chloride
• Keywords:
  Author Keywords: Dose-response Relation Dose-response Hepatotoxicity Hepatotoxins Humans Liver-cancer Liver-damage Liver-disorders Liver Angiosarcoma Liver Cancer Mortality-data Mortality-rates Mortality-surveys Statistical-analysis Vinyl Chloride

  More +
• ISSN:
  1044-3983
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  12
• Issue:
  6
• NIOSHTIC Number:
  nn:20021922
• Citation:
  Epidemiology 2001 Nov; 12(6):710-718
• Contact Point Address:
  Paolo Boffetta, International Agency for Research on Cancer, 150 cours Albert-Thomas, 69008 Lyon, France
• CAS Registry Number:
  Vinyl chloride (CAS RN 75-01-4)
• Federal Fiscal Year:
  2002
• Peer Reviewed:
  True
• Source Full Name:
  Epidemiology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8ea58febdb145e9929e6bb54a7e1a56357f5db1ca6336e3dc44c77885ce60333064ea1b956d69fc341e19896a7c8ecd886d6f0969d2b76b508f5fe416fc27122
• Download URL:
  https://stacks.cdc.gov/view/cdc/199001/cdc_199001_DS1.pdf
• File Type:
  [PDF - 127.15 KB ]