Epidemiologic investigation of occupational carcinogenesis using a serially additive expected dose model.

Details

• Personal Author:
  Smith AH ; Tyroler HA ; Waxweiler, Richard J.
• Description:
  A serially additive expected dose model that epidemiologically analyzed carcinogenic agents present in the work environment is discussed. This model is based on the cumulative dose concept and compares the observed exposure of each worker with the exposures of fellow workers close to the worker in year of birth, and in age of commencement of work for the company being studied. Expected and observed exposures are calculated for each worker and exposure levels and duration are taken into consideration. This method is applied to a study of angiosarcomas of the liver and vinyl chloride exposures in a polymerization facility. The authors conclude that this model generates important amounts of information associated with chemical exposures and cancer, including exposure level relationships, latency data, and the synergistic possibility of chemicals. [Description provided by NIOSH]
• Subjects:
  Age Factors Epidemiology Liver Neoplasms Occupational Exposure Occupational Health Plastics Safety Vinyl Chloride Workplace
• Keywords:
  Age-factors Author Keywords: Angiosarcoma Cancer Dose-response Epidemiologic Methods Humans Liver-cancer Occupational-exposure Occupational Diseases Synergism Vinyl Chloride Workplace-studies

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• ISSN:
  0002-9262
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  North Carolina ; Ohio ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  112
• Issue:
  6
• NIOSHTIC Number:
  nn:00104926
• Citation:
  Am J Epidemiol 1980 Dec; 112(6):787-797
• Contact Point Address:
  Dr. A. H. Smith, Department of Community Health, Wellington Clinical School of Medicine, Wellington Hospital, Wellington 2, New Zealand
• Federal Fiscal Year:
  1981
• Peer Reviewed:
  True
• Source Full Name:
  American Journal of Epidemiology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:17a1d9b24b6b0f41ba36d50c8b77ee2922bac17183e543810b7a1a747f20ecd7baef77508696e871712a90ab408408c9293b5f83de295ad51ae81920bc5825fb
• Download URL:
  https://stacks.cdc.gov/view/cdc/184374/cdc_184374_DS1.pdf
• File Type:
  [PDF - 655.38 KB ]