Molecular Mechanisms of Metal Toxicity and Carcinogenesis

Details

• Personal Author:
  Shi X ; Wang S ; Shi X ; Wang S
• Description:
  Many metals and metal-containing compounds have been identified to be potent mutagens and carcinogens. Recently, a new sub-discipline of molecular toxicology and carcinogenesis has been developed. The combination of newly developed molecular techniques and free radical approach makes it possible to insightfully examine metal-induced carcinogenesis in precise molecular terms so that intricate biological interrelationships can be elucidated. In consideration of the increased amount of new findings deciphered by utilizing these new methods, the 1st Conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis was held. In this conference, more than 50 scientists from nine countries presented their novel discoveries concerning metal-induced carcinogenesis, delineated molecular mechanism of metal carcinogenesis, and proposed novel therapeutic intervention and prevention strategies. This article reviews some of the state-of-the-art information presented at the meeting regarding the molecular mechanisms of metal cytotoxicity and carcinogenesis. [Description provided by NIOSH]
• Subjects:
  Carcinogens Cytotoxins Environmental Exposure Hazardous Substances Metals Metals, Heavy Metal Workers Mutagens Occupational Exposure Occupational Health Safety

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• Keywords:
  Author Keywords: ROS Carcinogenesis Cell-function Cell-growth Cell Growth Regulation Cytotoxic-effects Cytotoxicity Cytotoxicity And Carcinogenesis Environmental-exposure Heavy-metals Metal-compounds Metallic-compounds Metallic-minerals Metalworking Occupational-exposure Occupational-hazards Signal Transduction Toxic-materials Toxins Transcription Factor

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• ISSN:
  0300-8177
• Document Type:
  Text
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  3-9
• Volume:
  222
• Issue:
  1
• NIOSHTIC Number:
  nn:20021920
• Citation:
  Mol Cell Biochem 2001 Jun; 222(1-2):3-9
• Federal Fiscal Year:
  2001
• Peer Reviewed:
  True
• Source Full Name:
  Molecular and Cellular Biochemistry
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6ef96b6469d2f283e46f8cb90b8e3a4f66303dcf60f38b19e33d2c33ce913ba6839352664c354debe5e3d8a2bcb02a11cd91e718fb1ded65a8ed397c6ced9cd8
• Download URL:
  https://stacks.cdc.gov/view/cdc/199000/cdc_199000_DS1.pdf
• File Type:
  [PDF - 67.62 KB ]