Roles of Glia in Developmental Neurotoxicity: Session VI Summary and Research Needs

Details

• Personal Author:
  Aschner M ; Guerri C ; Matsushima GK ; O'Callaghan JP ; Streit WJ ; Tiffany-Castiglioni E
• Description:
  The purpose of this session was to address the molecular, pathological, and functional responses of astroglia, microglia, and oligodendroglia to neurotoxicant exposure. Neurons are the signaling cells of the nervous system, and as such are responsible for the perception of sensory stimuli and the coordination of cellular, tissue, and organismal responses to stimuli from the environment. Neuronal function and nervous tissue structure requires the participation of neuroglia, or glia, including astroglia (which participate in neurotransmitter metabolism and responses to stress and injury), radial glia and Bergmann glia (which provide scaffolding for neuronal migration during development), oligodendroglia and Schwann cells (which myelinate axons in the central and peripheral nervous systems, respectively), and microglia (which mediate inflammatory responses in the central nervous system). The roles of each of these cells as target cells and participants in various aspects of developmental neurotoxicity was discussed. [Description provided by NIOSH]
• Subjects:
  Environmental Exposure Nervous System Occupational Health Pathology Safety
• Keywords:
  Central-nervous-system Environmental-exposure Nervous-system Neurotoxicity Stimulants
• ISSN:
  0161-813X
• Publisher:
  Intox Press, Inc.
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Florida ; North Carolina ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 6 ; Texas ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  22
• Issue:
  5
• NIOSHTIC Number:
  nn:20021894
• Citation:
  Neurotoxicology 2001 Oct; 22(5):567-73
• Editor(s):
  Cranmer JM
• Federal Fiscal Year:
  2002
• NORA Priority Area:
  Other Occupational Concerns ; Neurotoxic Disorders
• Peer Reviewed:
  True
• Source Full Name:
  Neurotoxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6641b315247ce78f7878de7f7590dc083e40c4a47db74b273393743ad54c211c15b2980c8095c252d3281afa58589ca8feedefb3887d313fa47dcbd4cc8247d7
• Download URL:
  https://stacks.cdc.gov/view/cdc/198980/cdc_198980_DS1.pdf
• File Type:
  [PDF - 88.75 KB ]