Risk Assessment for 2,3, 7,8-P-Dioxin (TCDD) Based on an Epidemiologic Study

Details

• Personal Author:
  Deddens J ; Piacitelli, Laurie A. ; Steenland, Kyle
• Description:
  The International Agency for Research on Cancer (Lyon, France) recently concluded that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a human carcinogen. There have been few human studies and risk assessments with quantitative exposure data. The authors previously conducted exposure-response analyses based on estimated external TCDD exposure for 3,538 US male chemical workers and found a positive trend for all cancer with increasing cumulative exposure. In the present study, 1988 data from 170 workers with both estimated external exposure and known serum TCDD levels were used to derive the relation between the two. This derived relation was used to estimate serum TCDD levels over time for all 3,538 workers, and new dose-response analyses were conducted by using cumulative serum level. A positive trend (p = 0.003) was found between estimated log cumulative TCDD serum level and cancer mortality. For males, the excess lifetime (75 years) risk of dying of cancer given a TCDD intake of 1.0 pg/kg of body weight per day, twice the background intake, was an estimated 0.05-0.9% above a background lifetime risk of cancer death of 12.4%. Data from this cohort are consistent with another epidemiologic risk assessment from Germany and support recent conclusions by the US Environmental Protection Agency. [Description provided by NIOSH]
• Subjects:
  Carcinogens Dioxins Environmental Exposure Environmental Monitoring Manufacturing And Industrial Facilities Occupational Health Risk Assessment Safety Workplace
• Keywords:
  Author Keywords: Carcinogens Chemical-factory-workers Chemical-industry-workers Exposure-assessment Exposure-levels Exposure-limits Factory-workers Industrial-exposures Industrial-factory-workers Risk-analysis Risk Assessment Work-environment Workplace-studies

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• ISSN:
  0002-9262
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  451-458
• Volume:
  154
• Issue:
  5
• NIOSHTIC Number:
  nn:20021878
• Citation:
  Am J Epidemiol 2001 Sep; 154(5):451-458
• Contact Point Address:
  Dr. Kyle Steenland, Robert A. Taft Laboratories, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, Cincinnati, OH 45226-1998
• Email:
  kns1@cdc.gov
• CAS Registry Number:
  2,3,7,8-Tetrachlorodibenzo-p-dioxin (CAS RN 1746-01-6)
• Federal Fiscal Year:
  2001
• Peer Reviewed:
  True
• Source Full Name:
  American Journal of Epidemiology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3a1f6dab37d407a4256846c79c2f84fca57d6971742aef0ad1f47d8dab897fc18e42ae99d5e447ea7363f825efd5fd0ca3c5882b79d95011bcfbf1afba28d68d
• Download URL:
  https://stacks.cdc.gov/view/cdc/198965/cdc_198965_DS1.pdf
• File Type:
  [PDF - 124.62 KB ]