Time Course of Pulmonary Response of Rats to Inhalation of Crystalline Silica: Histological Results and Biochemical Indices of Damage, Lipidosis, and Fibrosis

Details

• Personal Author:
  Barger M ; Battelli L ; Castranova, Vincent ; Hubbs, Ann F. ; Jones, William G. ; Khan A ; Landsittel D ; Ma J ; McLaurin J ; Porter DW ; Ramsey D ; Robinson VA ; Teass A
• Description:
  Previous studies have determined that alpha-quartz (crystalline silica) can cause pulmonary inflammation, damage, and fibrosis. However, the temporal relationship between silica inhalation and pulmonary inflammation, damage, and fibrosis has not been fully examined. To address this gap in our knowledge of silica-induced pulmonary fibrosis, a chronic inhalation study using rats was designed. Specifically, rats were exposed to a silica aerosol (15 mg/m3 silica, 6 h/d, 5 d/wk, 116 d), and measurements of pulmonary inflammation, damage, and fibrosis were monitored throughout the study. We report (1) data demonstrating that the silica aerosol generation and exposure system produced a consistent silica aerosol of respirable size particles; (2) the time course of silica deposition in the lung; (3) calculations that demonstrate that the rats were not in pulmonary overload; (4) histopathological data demonstrating time-dependent enhancement of silica-induced alveolitis, epithelial hypertrophy and hyperplasia, alveolar lipoproteinosis, and pulmonary fibrosis in the absence of overload; and (5) biochemical data documenting the development of lipidosis, lung damage, and fibrosis. [Description provided by NIOSH]
• Subjects:
  Dust Fibrosis Lung Occupational Health Quartz Respiratory System Safety Silicon Dioxide Silicosis
• Keywords:
  Alveolar Lipoproteinosis Author Keywords: Alpha-quartz Exposure-levels Inhalation-studies Inhalation Exposure Pulmonary-system Pulmonary Fibrosis Quartz-dust Silica Silica-dusts
• ISSN:
  0731-8898
• Publisher:
  Begell House Inc.
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-14
• Volume:
  20
• NIOSHTIC Number:
  nn:20021840
• Citation:
  J Environ Pathol Toxicol Oncol 2001 Jan; 20(Suppl 1):1-14
• CAS Registry Number:
  Quartz (SiO2) (CAS RN 14808-60-7) ; Silica (CAS RN 7631-86-9)
• Editor(s):
  Moran EM
• Federal Fiscal Year:
  2001
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Environmental Pathology, Toxicology, and Oncology
• Supplement:
  1
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1bb452dd58cd5c22958818a6708f50ba5ae2e144205f4fd9fa2be4ea872366af939ca34f80ecfe1ab05606060a49e08a54183949b3177d17385540c932a3b5dd
• Download URL:
  https://stacks.cdc.gov/view/cdc/198936/cdc_198936_DS1.pdf
• File Type:
  [PDF - 1.23 MB ]