IgG Subclass Responses in Experimental Silicosis

Details

• Personal Author:
  Huang SH ; Hubbs, Ann F. ; Ma JKH ; Rojanasakul Y ; Stanley CF ; Weissman, David N.
• Description:
  Silicosis is a crippling fibrotic lung disease induced by inhaling crystalline silica. In addition to fibrosis, silica inhalation by humans is associated with a number of immunological effects including increased levels of serum immunoglobulins (in particular IgG), increased prevalence of autoantibodies, and autoimmune disease. Recent studies using rodent models have shown that experimental silicosis is associated with a T-helper (TH)1 pattern of T-cell activation in the lungs and lung-associated lymph nodes after silica inhalation, which are also the sites of increased IgG production. We therefore hypothesized that the subclass distribution of IgG production occurring in experimental silicosis would suggest TH1 activation as the primary stimulus for IgG production. Using an ELISPOT assay, we found increased IgG-secreting spot-forming cells of all IgG subclasses in lung-associated lymph nodes taken from silica-exposed rats 3 to 4 months after aerosol exposure to silica. Neither TH1- nor TH2-dependent IgG subclass-secreting cells were selectively enhanced. Our findings suggest that TH1 activation alone does not account for increased production of IgG in experimental silicosis. [Description provided by NIOSH]
• Subjects:
  Aluminum Silicates Animals Dust Environmental Monitoring Fibrosis Immune System Laboratories Lung Lung Diseases Occupational Health Quartz Respiratory System Respiratory Tract Diseases Safety Silicon Dioxide Silicosis

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• Keywords:
  Animal-studies Author Keywords: Silicosis Cytokine Diseases Exposure-assessment IgG Immunologic-disorders Laboratory-animals Lung Lung-disease Lung-fibrosis Lymph-nodes Lymphocyte Pulmonary-system-disorders Quartz Quartz-dust Respiratory-system-disorders Silica-dusts Silicates

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• ISSN:
  0731-8898
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  67-74
• Volume:
  20
• NIOSHTIC Number:
  nn:20021926
• Citation:
  J Environ Pathol Toxicol Oncol 2001 Jan; 20(Suppl 1):67-74
• Contact Point Address:
  National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Analytical Services Branch, 1095 Willowdale Road, Morgantown, WV 26505
• Email:
  dqw4@cdc.gov
• CAS Registry Number:
  Quartz (SiO2) (CAS RN 14808-60-7)
• Federal Fiscal Year:
  2001
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Environmental Pathology, Toxicology, and Oncology
• Supplement:
  1
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ca0ba8cc825537280a5664ac531294ca7dc47e6f55e5bdea24ee6c609c6a7bc9c774ea5060583f5f4f8df2ad145d8bb440d57427d1c4e3d6f0f310b838458f2d
• Download URL:
  https://stacks.cdc.gov/view/cdc/199003/cdc_199003_DS1.pdf
• File Type:
  [PDF - 284.85 KB ]